Results 61 to 70 of about 42,229 (197)

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Fas/CD95 Ligation Induces Proliferation of Primary Fetal Astrocytes Through a Mechanism Involving Caspase 8-Mediated ERK Activation

Cellular Physiology and Biochemistry, 2013
Background: Fas/CD95 is the best-studied member of the death receptor (DR) superfamily in the central nervous system where it can trigger cellular responses other than apoptosis, including the promotion of neurogenesis and neuritogenesis, stimulation of ...
Olga Barca, Marcos Seoane, Rosa Mª Señarís, Víctor M. Arce   +3 more
doaj   +1 more source

Характеристика соотношения маркеров активации и апоптоза в крови пациентов с демодикозной инвазией [PDF]

, 2010
Досліджено імунологічні показники у 125 пацієнтів з демодикозом. Показано, що при розвитку демодикозної інвазії несприятливим вважається підвищення рівня CD25+, HLA-DR+, CD95+ маркерів, зниження співвідношень CD4+/CD95+, CD8+/CD95+, підвищення ...
Кусая, Н.В., Маркелова, Е.В., Юцковский, А.Д.   +2 more
core  

Role of mitochondrial raft-like microdomains in the regulation of cell apoptosis [PDF]

, 2015
Lipid rafts are envisaged as lateral assemblies of specific lipids and proteins that dissociate and associate rapidly and form functional clusters in cell membranes.
A Al-Saif, A Bertoni, A Cossarizza, A Ferri, A Israelson, A Raturi, A Valencia, A Valencia, AA Rowland, AE Rusinol, AL Nishimura, AL Wozniak, Alberto Ferri, AM Giammarioli, AO Hueber, B Kornmann, C Barbat, C Brooks, C Dall’Armi, C Frezza, C Gajate, C Garcia-Ruiz, C Garcia-Ruiz, C Martel, C Steinmann, C Vande Velde, CB Pickett, CD Austin, CH Chou, CL Schengrund, D Naon, D Scheel-Toellner, D Scheel-Toellner, DF Legler, DF Suen, DT Browman, E Bossy-Wetzel, E Lai, E Szegezdi, EM Lynes, EM Lynes, F Korobova, F Mollinedo, G Csordas, G Szabadkai, GC Shore, GM Cereghetti, H Grassmè, H Yano, I Annunziata, I Poggiolini, J Faitova, J Katz, J Stiban, JC Martinou, JC Wanson, JE Vance, JL Herrera, JR Friedman, JT Vollrath, K Banki, K Simons, K Simons, KF Ferri, KR Pitts, L Ciarlo, L Ciarlo, L Dupuis, L Scorrano, LA Lewis, M Cozzolino, M Cozzolino, M Degli Esposti, M Degli Esposti, M Fujimoto, M Hamasaki, M Hamasaki, M Karbowski, M Lutter, M Satoh, M Sorice, M Sorice, M Sorice, M Sorice, M Sorice, M Vey, Maria Grasso, Maurizio Sorice, ME Soriano, MG Martín, MM Young, MR Rippo, MT Dimanche-Boitre, N Myhill, N Naslavsky, N Zurgil, NT Watt, OM Brito de, OM Brito de, P Matarrese, P Matarrese, P Matarrese, P Pizzo, P Pizzo, P Pizzo, PA Parone, PJ Meier, R Rizzuto, R Rizzuto, R Sano, R Stoica, RG Burns, RM Siegel, Roberta Misasi, S Ayala-Peña, S Cipolat, S Eda, S Hoppins, S Montessuit, S Orrenius, S Ouasti, S Sonnino, SB Prusiner, SW Ahn, SY Gilady, T Garofalo, T Garofalo, T Gutierrez, T Hayashi, T Hayashi, T Hayashi, T Hayashi, T Kuwana, T Simmen, T Simmen, Tina Garofalo, UP Shirendeb, V Lallemand-Breitenbach, V Mattei, V Mattei, V Mattei, Valeria Manganelli, Vincenzo Mattei, W Hu, W Malorni, W Song, W Song, X Guo, Y Higuchi, Y Yoon, Y Zhang, YJ Lee, Z Sui, Z Wieslaw   +153 more
core   +1 more source

Apoptosis kinetics of purified and PBMC‐associated lymphocytes after photopheresis‐like 8‐methoxypsolaren/UVA treatment

Photochemistry and Photobiology, EarlyView.
Extracorporeal photopheresis (ECP) induces apoptosis in circulating immune cells, but its kinetics vary slightly depending on the cell type. We compared the progression of apoptosis in PBMCs versus highly purified T cells exposed to 8‐methoxypsoralen and ultraviolet A.
Carlos Agustin Villegas‐Valverde, Imilla Casado Hernandez, Yandy Marx Castillo‐Aleman, Gisela Maria Suarez‐Formigo, Amar Riaz, Antonio Alfonso Bencomo‐Hernandez, Yendry Ventura‐Carmenate   +6 more
wiley   +1 more source

IRE1 RNase controls CD95-mediated cell death

EMBO Reports
Signalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) are frequently activated towards pro-tumoral outputs in cancer. Herein, we demonstrate that the UPR sensor IRE1 controls the expression of the DR CD95/Fas, and its cell ...
Diana Pelizzari-Raymundo, Victoria Maltret, Manon Nivet, Raphael Pineau, Alexandra Papaioannou, Xingchen Zhou, Flavie Caradec, Sophie Martin, Matthieu Le Gallo, Tony Avril, Eric Chevet, Elodie Lafont   +11 more
doaj   +1 more source

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source

Higher Expression of Activated CD8+ T Lymphocytes (CD8+CD25+, CD8+CD69+ and CD8+CD95+) Mediate Early Post-Transplant Acute Tubular Injury in Kidney Recipients

Frontiers in Bioscience-Landmark, 2023
Background: Acute kidney injury (AKI) is a leading cause of early post-transplant kidney damage. Furthermore, acute tubular necrosis (ATN) is appointed as the most prevalent form of AKI, a frequent multifactorial process associated with high morbidity ...
Francisco Boix, Víctor Jimenez-Coll, Isabel Legaz, Rafael Alfaro, Maria R. Moya-Quiles, Jesús de la Peña-Moral, Alfredo Minguela, Santiago Llorente, Manuel Muro   +8 more
doaj   +1 more source

Metalloprotease‐mediated cleavage of CD95 ligand

The FEBS Journal, 2023
CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the transduction of either apoptotic or nonapoptotic signals.
Risso, Vesna, Thomas, Mélissa, Guével, Blandine, Lavigne, Regis, Com, Emmanuelle, Martin, Sophie, Nivet, Manon, Pineau, Charles, Negroni, Luc, Lafont, Elodie, Chevet, Eric, Eriksson, Leif, Le Gallo, Matthieu   +12 more
openaire   +2 more sources

Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3‐Induced T Cell Activation in Preclinical Models

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
In OKT3‐treated human PBMCs, Wnt signaling was downregulated, and co‐treatment with the Wnt activator CHIR99021 reduced T cell activation and apoptosis. In humanized mice, transcriptomic profiling revealed upregulation of genes associated with T cell activation, cytokine and ROS production, and apoptosis, with downregulation of canonical Wnt signaling.
Myeongjin Choi, Duhyeon Park, Da‐Hee Lee, Chang Hoon Choi, Minseong Jo, Seo Yule Jeong, Seung Yeon Lim, Daeui Park, Kyoung‐Sik Moon   +8 more
wiley   +1 more source