CD95/Fas ligand mRNA is toxic to cells through more than one mechanism [PDF]
Molecular Biomedicine, 2023 CD95/Fas ligand (CD95L) induces apoptosis through protein binding to the CD95 receptor. However, CD95L mRNA also induces toxicity in the absence of CD95 through induction of DISE (Death Induced by Survival Gene Elimination), a form of cell death mediated
Ashley Haluck-Kangas +3 more
doaj +2 more sources
Role of metalloproteases in the CD95 signaling pathways [PDF]
Frontiers in Immunology, 2022 CD95L (also known as FasL or CD178) is a member of the tumor necrosis family (TNF) superfamily. Although this transmembrane ligand has been mainly considered as a potent apoptotic inducer in CD95 (Fas)-expressing cells, more recent studies pointed out ...
Laurent Devel +5 more
doaj +2 more sources
The dual role of the CD95 and CD95L signaling pathway in glioblastoma [PDF]
Frontiers in Immunology, 2022 Binding of CD95, a cell surface death receptor, to its homologous ligand CD95L, transduces a cascade of downstream signals leading to apoptosis crucial for immune homeostasis and immune surveillance.
Yanrui Zhang +7 more
doaj +2 more sources
Airway epithelial cells and macrophages trigger IL-6-CD95/CD95L axis and mediate initial immunopathology of COVID-19 [PDF]
iScience, 2023 Summary: Airway epithelial cells (AEC) infected with SARS-CoV-2 may drive the dysfunction of macrophages during COVID-19. We hypothesized that the direct interaction of AEC with macrophages mediated by CD95/CD95L or indirect interaction mediated by IL-6 ...
Thais F.C. Fraga-Silva +17 more
doaj +2 more sources
High yield purification of an isoleucine zipper-modified CD95 ligand for efficient cell apoptosis initiation and with biotin or DNA-oligomer binding domain to probe ligand functionalization effects [PDF]
BMC BiotechnologyBackground Cluster of differentiation 95 (CD95/Fas/Apo1) as part of the Tumor-necrosis factor (TNF) receptor family is a prototypic trigger of the ‘extrinsic’ apoptotic pathway and its activation by the trimeric ligand CD95L is of high interest. However,
Xiaoyue Shang +7 more
doaj +2 more sources
CD95 gene deletion may reduce clonogenic growth and invasiveness of human glioblastoma cells in a CD95 ligand-independent manner [PDF]
Cell Death Discovery, 2022 CD95 (Fas/APO-1) is a multifunctional cell surface receptor with antithetic roles. First described to mediate cell death, interactions of CD95 with its natural ligand, CD95L, have also been described to induce tumor-promoting signaling leading to ...
Clara Quijano-Rubio +2 more
doaj +2 more sources
Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway. [PDF]
PLoS Biology, 2023 [This corrects the article DOI: 10.1371/journal.pbio.1001090.].
Sébastien Tauzin +13 more
doaj +3 more sources
IRE1 RNase controls CD95-mediated cell death [PDF]
EMBO ReportsSignalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) are frequently activated towards pro-tumoral outputs in cancer. Herein, we demonstrate that the UPR sensor IRE1 controls the expression of the DR CD95/Fas, and its cell ...
Diana Pelizzari-Raymundo +11 more
doaj +2 more sources
Oligomerised RIPK1 is the main core component of the CD95 necrosome [PDF]
The EMBO JournalThe necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in multicellular organisms.
Nikita V Ivanisenko +8 more
doaj +2 more sources
Indonesian Journal of Cancer, 2022 Background: Programmed Death Ligand (PD-L1) and Cluster of Differentiation 95 (CD95L) are influenced by oncogenes and function in the anti-apoptosis process which is thought to play a role in chemotherapy resistance.
Hasrayati Agustina +2 more
doaj +1 more source