Results 91 to 100 of about 6,938 (195)

Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment. [PDF]

, 2017
The mechanisms of how chemotherapeutic drugs lead to cell cycle checkpoint regulation and DNA damage repair are well understood, but how such signals are transmitted to the cellular apoptosis machinery is less clear.
Albarenque, Stella-Maris, Deedigan, Laura, Houlden, Lily, Jencz, Sylwia, Mehrabadi, Yasamin, Mohr, Andrea, Zwacka, Ralf M   +6 more
core   +1 more source

Progress in Research on Regulated Cell Death in Cerebral Ischaemic Injury After Cardiac Arrest

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Ischaemic damage to the brain is the main cause of brain injury after cardiac arrest. The current treatment focuses on early reperfusion, but reperfusion tends to cause reperfusion injury, which is a significant problem. Cell death is an irreversible and normal end to cell life, playing key roles in maintaining the homeostasis and development ...
Zumin Chen, Shuangwei Wang, Tian Shu, Senlin Xia, Yanmei He, Yanhan Yang   +5 more
wiley   +1 more source

Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death [PDF]

, 2017
Although inhibition of the epidermal growth factor receptor is a plausible therapy for malignant gliomas that, in vitro, enhances apoptosis, the results of clinical trials have been disappointing.
Brucker, Daniel P., Burger, Michael C., Rieger, Johannes, Ronellenfitsch, Michael W., Steinbach, Joachim P., Tritschler, Felix, Weller, Michael, Wick, Wolfgang, Wolking, Stefan   +8 more
core  

Convergent evolution of pregnancy-specific glycoproteins in human and horse [PDF]

, 2016
Pregnancy-specific glycoproteins (PSGs) are members of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family that are secreted by trophoblast cells. PSGs may modulate immune, angiogenic and platelet responses during pregnancy.
Amanda M de Mestre, Baker, Denis Aleksic, Donaldson, Fialova, Jana Hänske, Johannes Handler, Jordan E Read, Lisa Blaschke, Robert Kammerer, Ronan O’Riordan, Schumacher, Sophie Mißbach, Tom Moore, Victoria Cabrera-Sharp, Wiebke Weiß, Wolfgang Zimmermann   +16 more
core   +2 more sources

In Vivo Interactions of Nucleic Acid Nanostructures With Cells

Advanced Materials, Volume 37, Issue 2, January 15, 2025.
Nucleic acid nanostructures have been intracellular drug carriers for nanomedicine applications for two decades, but their interaction with cells in vivo has gained clarity only recently. This review features their cellular‐level distribution in various organs and the cellular responses induced in rodents, large animals, and humans.
Yu Xiao, Zhihui Liang, Moldir Shyngys, Aiana Baekova, Suen Cheung, Mathias Billy Muljadi, Qianqian Bai, Lula Zeng, Chung Hang Jonathan Choi   +8 more
wiley   +1 more source

Function and Spatial Organization of Tumor‐Invasive Human γδ T Cells—What Do We Know?

European Journal of Immunology, Volume 55, Issue 1, January 2025.
This review provides deeper insights into the localization of intra‐tumoral γδ T lymphocytes in solid tumors. Additionally, a pro‐ or anti‐tumoral influence of the tumor microenvironment and expression of checkpoint inhibitory molecules on γδ T cell functionality is described.
Kilian Wistuba‐Hamprecht, Hans‐Heinrich Oberg, Daniela Wesch   +2 more
wiley   +1 more source

Cytotoxic activity of peripheral blood lymphocytes in children with infectious mononucleosis

Бюллетень сибирской медицины, 2009
Twenty children aged 3—6 years with Epstein—Barr-virus-induced infectious mononucleosis (IM) were examined. The present study is aimed at investigating the functional activity of cytotoxic lymphocytes in children with IM during clinical and hematological
N. R. Slepicheva, O. I. Urazova, V. V. Novitsky, A. P. Pomogayeva   +3 more
doaj   +1 more source

Hippocampal myelin damage contributes to cognitive impairment in a rat model of trigeminal neuropathic pain: Neuroprotective and anti-inflammatory effects of atorvastatin

Neuroscience Research
Chronic neuropathic pain is increasingly recognized to impair cognitive function, yet its underlying mechanisms remain unclear. This study tested whether trigeminal neuropathic pain (TNP) modeled by distal infraorbital nerve chronic constriction injury ...
Yongkui Yang, Youzhi Ning, Shuangchun Peng, Changli Liao, Jia Fu, Jiaomei Zhao, Cehua Ou, Yue Zhang   +7 more
doaj   +1 more source

Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells [PDF]

, 2018
Acute inflammation is a complex and tightly regulated homeostatic process that includes leukocyte migration from the vasculature into tissues to eliminate the pathogen/injury, followed by a pro-resolving response promoting tissue repair.
Achuthan, Alivernini, Alivernini, Alvaro-Gracia, Anderson, Asquith, Bamboat, Behrens, Bell, Ben Nasr, Benham, Black, Bluml, Brentano, Burmester, Burmester, Burmester, Catrina, Cauli, Cheung, Chu, Chu, Couzin-Frankel, Cramer, Cross, den Berg, den Brand, Dillon, Donlin, Ehrenstein, Elmesmari, Ferraccioli, Field, Firestein, Frank-Bertoncelj, Gao, Ginhoux, Greven, Guiducci, Guo, Hambleton, Hamilton, Haschka, Herenius, Hogg, Hurst, Iliev, James, Jongbloed, Kaplanski, Kokkonen, Kollias, Konig, Kriegler, Kurowska-Stolarska, Kurowska-Stolarska, Kurowska-Stolarska, Lemke, Malmstrom, Mann, McInnes, McInnes, McInnes, McLoughlin, Midwood, Miller, Misharin, Misso, Moret, Moret, Morton, Murata, Na, Nagy, Nassar, Ng, O'Connell, O'Connell, O'Keeffe, Ohshima, Okada, Paolino, Park, Rajasekhar, Ramwadhdoebe, Rauber, Reynolds, Roberts, Rothlin, Rupaimoole, Rycke, Sacre, Schett, Singh, Smith, Smith, Smolen, Sokolove, Stanczyk, Steidl, Takeuchi, Tannahill, Thai, Tsoumakidou, Udalova, Vandenabeele, Villani, Watts, Weinblatt, Weiss, Williamson, Wolf, Xiong, Yeo, Yu, Zou   +115 more
core   +1 more source

Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1. [PDF]

, 2014
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in many cancer cells without causing toxicity in vivo. However, to date, TRAIL-receptor agonists have only shown limited therapeutic benefit in clinical trials. This can,
Abd El Hay, M, Arce, F, Conti, A, El-Bahrawy, MA, Lemke, J, Montinaro, A, Papenfuss, K, von Karstedt, S, Walczak, H   +8 more
core