Results 21 to 30 of about 6,938 (195)

Cleaved CD95L perturbs in vitro macrophages responses to Toxoplasma gondii

Microbes and Infection, 2022
Toxoplasma gondii infects approximately 1-2 billion people, and manipulation of the macrophage response is critical to host and parasite survival. A cleaved (cl)-CD95L form can promote cellular migration and we have previously shown that cl-CD95L aggravates inflammation and pathology in systemic lupus erythematosus (SLE). Findings have shown that CD95L
Tiffney, Ellen A, Coombes, Janine L, Legembre, Patrick, Flynn, Robin J   +3 more
openaire   +4 more sources

Inhibition of NF‐κB induces a switch from CD95L‐dependent to CD95L‐independent and JNK‐mediated apoptosis in T cells [PDF]

FEBS Letters, 2010
NF‐κB is a crucial transcription factor regulating apoptosis sensitivity and resistance. It has been shown that inhibition of NF‐κB in T lymphocytes leads to sensitization towards apoptosis. The underlying molecular mechanism is not entirely understood.
Kießling, Michael K., Linke, Björn, Brechmann, Markus, Süss, Dorothee, Krammer, Peter H., Gülow, Karsten   +5 more
openaire   +2 more sources

Precise mapping of the CD95 pre-ligand assembly domain. [PDF]

, 2012
International audiencePre-association of CD95 at the plasma membrane is mandatory for efficient death receptor signaling. This homotrimerization occurs through self-association of an extracellular domain called the pre-ligand assembly domain (PLAD ...
Daburon, Sophie, Edmond, Valérie, Ghali, Benoist, Legembre, Patrick, Moreau, Jean-François, Penna, Aubin, Taupin, Jean-Luc   +6 more
core   +7 more sources

Reprimo (RPRM): A Tumor Suppressor That Induces Extrinsic Apoptosis via YAP Signaling. [PDF]

Cancer Sci
Reprimo (encoded by RPRM) is a p53 target gene that acts as a tumor suppressor and is frequently silenced by promoter hypermethylation in various cancers. Although previously known to function intracellularly as a tumor suppressor, recent studies revealed that secreted Reprimo also induces apoptosis in neighboring cells through a novel p53‐Reprimo ...
Takikawa M, Ohki R.
europepmc   +2 more sources

Marked mitigation of transplant vascular sclerosis in FasL(gld) (CD95L) mutant recipients. I. The role of alloantibodies in the development of chronic rejection [PDF]

, 1999
Background. In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death.
Aitouche, A, Fung, JJ, Rao, AS, Salam, A, Starzl, TE, Subbotin, V, Sun, H, Valdivia, LA   +7 more
core   +1 more source

Cytoplasmic Overexpression of CD95L in Esophageal Adenocarcinoma Cells Overcomes Resistance to CD95-Mediated Apoptosis

Neoplasia: An International Journal for Oncology Research, 2011
Introduction: The CD95/CD95L pathway plays a critical role in tissue homeostasis and immune system regulation; however, the function of this pathway in malignancy remains poorly understood.
Gregory A. Watson, Sanjay Naran, Xinglu Zhang, Michael T. Stang, Pierre E. Queiroz de Oliveira, Steven J. Hughes   +5 more
doaj   +1 more source

In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells [PDF]

, 2019
Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens
A Ashkenazi, A Cerwenka, A Hadji, A Orbach, AP Costa-Pereira, Baryshnikov AYu, C Fionda, H Cho, HA Elrod, I Viard-Leveugle, J Sträter, J Wu, JC Symes, K Yamamoto, L Boldrini, L Galligan, L Siena, M Christgen, M Mottolese, M Müller, M Todaro, M Villa-Morales, MA Park, ME Peter, N Gordon, O Micheau, PB Carvalho-Neto de, RW McGilvray, S Yang, V Almendro, WM Liu, Y Hirooka, Y Kimura   +32 more
core   +2 more sources

CD95 and CD95L promote and protect cancer stem cells [PDF]

Nature Communications, 2014
CD95 (APO-1/Fas) is a death receptor used by immune cells to kill cancer cells through induction of apoptosis. However, the elimination of CD95 or its ligand, CD95L, from cancer cells results in death induced by CD95R/L elimination (DICE), a type of cell death that resembles a necrotic form of mitotic catastrophe suggesting that CD95 protects cancer ...
Paolo, Ceppi, Abbas, Hadji, Frederick J, Kohlhapp, Abhinandan, Pattanayak, Annika, Hau, Xia, Liu, Huiping, Liu, Andrea E, Murmann, Marcus E, Peter   +8 more
openaire   +2 more sources

Topical imiquimod and in situ vulvar melanoma: A promising therapy? [PDF]

Int J Gynaecol Obstet
Abstract Objectives Vulvar melanoma is a rare type of cancer that affects mainly postmenopausal women. There are no established protocols for the treatment of vulvar melanoma. From data extrapolated from the literature on cutaneous melanoma, surgical excision remains the best option for the resectable disease.
Pepe F, Silvestri F, Preti EP, Iacobone AD, Radici G, Vaccari S, Queirolo P, Tosti G.   +7 more
europepmc   +2 more sources

Apoptosis of Inflammatory Cells in Immune Control of the Nervous System: Role of Glia [PDF]

, 2001
Normal individuals have T lymphocytes capable of reacting to central nervous system (CNS) antigens such as myelin basic protein (MBP) (Martin et al., [1990]). In view of recent evidence indicating that T cells are much more cross-reactive than previously
Alderson, Aloisi, Ashkenazi, Bachmann, Barac-Latas, Bauer, Bechmann, Boise, Bonetti, Brunner, Brüne, Chan, Choi, Chu, Collette, Deng, Dhein, Dittel, Flügel, Ford, Frei, Frigerio, Gold, Gordon, Groux, Hemmer, Hickey, Irani, Ishigami, Issazadeh, Ju, Kohji, Kohji, Körner, Lee, Li, Liu, Luo, MacPhee, Malipiero, Martin, Mason, Matsumoto, Matsumoto, Matsumoto, McCombe, McCombe, Mor, Mueller, Nguyen, Nguyen, Nguyen, Nieto, Ohmori, Okuda, Pender, Pender, Pender, Pender, Pender, Qian, Ren, Russell, Sabelko, Sabelko-Downes, Schmidt, Schmied, Schweitzer, Smith, Smith, Streit, Sun, Suvannavejh, Tabi, Tabi, Tan, Waldner, Weishaupt, Wekerle, Wenkel, White, White, White, Wildbaum, Wucherpfennig, Yang, Zacharchuk, Zeine, Zettl, Zipp   +89 more
core   +1 more source