Results 151 to 160 of about 6,757 (189)

Multi-armored mesenchymal stem cells potentiate antitumor immunity to combat ovarian cancer. [PDF]

Stem Cell Res Ther
Cao M, Tang Y, Li Y, Li J, Shen M, Hu L, Zhang Y, Li D, Wang D, Mao J, Shen J.   +10 more
europepmc   +1 more source

Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease. [PDF]

Sci Immunol
Fenton TM, Wulff L, Väänänen V, Jones GR, Lemvigh CK, Riis LB, Wewer MD, Vandamme J, Jørgensen PB, Bain CC, Belling KG, Ho GT, Pers TH, Poulsen A, Madsen GR, Nielsen OH, Jakobsen HL, Izarzugaza JM, Bendtsen F, Brunak S, Mowat AM, Olsen LR, Mörbe U, Agace WW.   +23 more
europepmc   +1 more source

Reframing adjuvant immunotherapy in melanoma: all of it starts with priming. [PDF]

J Immunother Cancer
Ascierto PA, Melero I.
europepmc   +1 more source

Antigen cross-presentation potentiating cancer vaccine adjuvant for T cell expansion and synergy with anti-PD-1. [PDF]

NPJ Vaccines
Dang GC, Loeurng V, Pa P, Seng CY, Lee SE, Rhee JH.   +5 more
europepmc   +1 more source

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells. [PDF]

Sci Immunol
Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Martinez-Krams D, Lau CM, Reyes J, Abdennur N, Shkolikov A, Yap GS, Khodadadi-Jamayran A, Dolgalev I, Mirny LA, Reizis B.   +14 more
europepmc   +1 more source

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cDC1 Vaccines Drive Tumor Rejection by Direct Presentation Independently of Host cDC1

Cancer Immunology Research, 2022
Abstract As a cell-based cancer vaccine, dendritic cells (DC), derived from peripheral blood monocytes or bone marrow (BM) treated with GM-CSF (GMDC), were initially thought to induce antitumor immunity by presenting tumor antigens directly to host T cells.
Stephen T. Ferris, Ray A. Ohara, Feiya Ou, Renee Wu, Xiao Huang, Sunkyung Kim, Jing Chen, Tian-Tian Liu, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy   +10 more
openaire   +2 more sources

Unexplored horizons of cDC1 in immunity and tolerance

Advances in Immunology, 2020
Dendritic cells are a specialized subset of hematopoietic cells essential for mounting immunity against tumors and infectious disease as well as inducing tolerance for maintenance of homeostasis. DCs are equipped with number of immunoregulatory or stimulatory molecules that interact with other leukocytes to modulate their functions.
Kristen Radford, Sreekumar Balan, Nina Bhardwaj   +2 more
exaly   +5 more sources

Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production

Cell Reports, 2023
Tissue-resident immune cells are critical to the initiation and potentiation of inflammation. However, the tissue-protective cellular communication networks initiated by resident immunity during sterile inflammation are not well understood. Using single-cell transcriptomic analysis, we show the liver-resident cell connectome and signalome during acute ...
Timothy O'Sullivan, Eddie T Padilla
exaly   +6 more sources

Cancer immunity derailed: PGE2 misconducts cDC1s

Immunity, 2023
Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.
Matthew Brown, Michelle A. Tran, Nina Bhardwaj   +2 more
openaire   +2 more sources

Zbtb10 transcription factor is crucial for murine cDC1 activation and cytokine secretion

European Journal of Immunology, 2021
Abstract Dendritic cell (DC) activation and cytokine production is tightly regulated. In this study, we found that Zbtb10 expression is activation dependent and it is essential for the immunogenic function of cDC1.
Sunil Kumar Raghav, Viplov Kumar Biswas, Arup Ghosh   +2 more
exaly   +3 more sources