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Mechanisms of CD40-dependent cDC1 licensing beyond costimulation
Nature Immunology, 2022CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-mediated tumor rejection, but the underlying mechanisms are incompletely understood. Here, we identified CD40-induced genes in cDC1s, including Cd70, Tnfsf9, Ptgs2 and Bcl2l1, and examined their contributions to anti-tumor immunity.
Renee Wu +13 more
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cDC1 to cDC2: “Everything I do, Ido1 it for you”
Immunity, 2022Distinct dendritic cell (DC) subsets exert specific functions in immune regulation, but their communication with each other has remained elusive. In this issue of Immunity, Gargaro et al. identify the IDO1-Kyn-AHR axis as a metabolic signaling pathway through which conventional DC subsets communicate and induce tolerogenicity.
Mirja Tamara, Prentzell +1 more
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Science, 2020
Tumor Immunology A subset of immune cells called conventional dendritic cell 1 (cDC1) has been shown to play a critical role in antitumor responses. Hubert et al. now show that human cDC1 contribute to antitumor responses through the production of type III interferon, also known as IFN-γ1.
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Tumor Immunology A subset of immune cells called conventional dendritic cell 1 (cDC1) has been shown to play a critical role in antitumor responses. Hubert et al. now show that human cDC1 contribute to antitumor responses through the production of type III interferon, also known as IFN-γ1.
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Immunity
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. propose that erythropoietin receptor signaling biases cDC1s toward a maturation state associated with ...
Victor, Bosteels, Sophie, Janssens
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Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. propose that erythropoietin receptor signaling biases cDC1s toward a maturation state associated with ...
Victor, Bosteels, Sophie, Janssens
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Cryptic activation of an Irf8 enhancer governs cDC1 fate specification [PDF]
Nature Immunology, 2019 Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction are unclear. In the present study Irf8 enhancers were identified via chromatin profiling of dendritic cells and CRISPR/Cas9 genome editing was ...
Swapneel Patel +2 more
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Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment
Trends in Immunology, 2022Interferon regulatory factor 8 (IRF8) has long been associated with conventional dendritic cell type I (cDC1) development. In a recent study, Lança et al. demonstrate that IRF8 is also crucial in cells already committed to the cDC1 lineage. Here, deletion of IRF8 from the XCR1-expressing pre-cDC1 stage onward leads to a loss of commitment and ...
Waller, Kathryn, Scott, Charlotte L.
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IRF8 and BATF3 interaction enhances the cDC1 specific Pfkfb3 gene expression
Cellular Immunology, 2022Dendritic cells (DCs) play central role in innate as well as adaptive immune responses regulated by diverse DC subtypes that vary in terms of surface markers, transcriptional profile and functional responses. Generation of DC diversity from progenitor stage is tightly regulated by complex molecular inter-play between transcription factors.
Kuldeep Singh Chauhan +6 more
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The Making of a
ABSTRACT The development of type 1 classical dendritic cells (cDC1s) from bone marrow progenitors is a multistage process directed by a complex transcriptional network. At its center is interferon regulatory factor‐8 (IRF8), the lineage‐determining factor whose precise, stage‐specific expression is integrated at ...
Theresa L. Murphy, Kenneth M. Murphy
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cDC1 craves glutamine for its glory
Nature Immunology, 2023Stefania Vilbois +2 more
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Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
ScienceConventional type 1 dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8 + T cells. How tumor antigens are processed to activate CD8 + T cell immunity is not well ...
Bowen Xie +18 more
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