Results 181 to 190 of about 8,545 (211)

cDC1 Vaccines Drive Tumor Rejection by Direct Presentation Independently of Host cDC1

Cancer Immunology Research, 2022
Abstract As a cell-based cancer vaccine, dendritic cells (DC), derived from peripheral blood monocytes or bone marrow (BM) treated with GM-CSF (GMDC), were initially thought to induce antitumor immunity by presenting tumor antigens directly to host T cells.
Stephen T. Ferris, Ray A. Ohara, Feiya Ou, Renee Wu, Xiao Huang, Sunkyung Kim, Jing Chen, Tian-Tian Liu, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy   +10 more
openaire   +2 more sources

A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity [PDF]

Cancer Cell, 2023
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but whether this determines protective versus ineffective anti-cancer immunity is poorly understood.
Leonhard Stark
exaly   +3 more sources

Unexplored horizons of cDC1 in immunity and tolerance

Advances in Immunology, 2020
Dendritic cells are a specialized subset of hematopoietic cells essential for mounting immunity against tumors and infectious disease as well as inducing tolerance for maintenance of homeostasis. DCs are equipped with number of immunoregulatory or stimulatory molecules that interact with other leukocytes to modulate their functions.
Kristen Radford, Sreekumar Balan, Nina Bhardwaj   +2 more
exaly   +5 more sources

Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production

Cell Reports, 2023
Tissue-resident immune cells are critical to the initiation and potentiation of inflammation. However, the tissue-protective cellular communication networks initiated by resident immunity during sterile inflammation are not well understood. Using single-cell transcriptomic analysis, we show the liver-resident cell connectome and signalome during acute ...
Timothy O'Sullivan
exaly   +6 more sources

Cancer immunity derailed: PGE2 misconducts cDC1s

Immunity, 2023
Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.
Matthew Brown, Michelle A. Tran, Nina Bhardwaj   +2 more
openaire   +2 more sources

Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses [PDF]

Frontiers in Immunology, 2023
Historically platelets are mostly known for their crucial contribution to hemostasis, but there is growing understanding of their role in inflammation and immunity.
Yvette van Kooyk, Joke M M Den Haan, Alsya Affandi   +2 more
exaly   +4 more sources

STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer [PDF]

Cancers, 2020
Conventional dendritic cells (cDCs) are a critical immune population, composed of multiple subsets, and responsible for controlling adaptive immunity and tolerance. Although migratory type 1 cDCs (CD103+ cDC1s in mice) are necessary to mount CD8+ T cell-mediated anti-tumor immunity, whether and how tumors modulate CD103+ cDC1 function remain ...
Haiyan Li, James J Mancuso, Taylor Chrisikos   +2 more
exaly   +3 more sources

Mechanisms of CD40-dependent cDC1 licensing beyond costimulation

Nature Immunology, 2022
CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-mediated tumor rejection, but the underlying mechanisms are incompletely understood. Here, we identified CD40-induced genes in cDC1s, including Cd70, Tnfsf9, Ptgs2 and Bcl2l1, and examined their contributions to anti-tumor immunity.
Renee Wu, Ray A. Ohara, Suin Jo, Tian-Tian Liu, Stephen T. Ferris, Feiya Ou, Sunkyung Kim, Derek J. Theisen, David A. Anderson, Brian W. Wong, Timothy Gershon, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy   +13 more
openaire   +2 more sources

Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity [PDF]

Frontiers in Immunology, 2019
Dendritic cells (DCs) efficiently process and present antigens to T cells, and by integrating environmental signals, link innate and adaptive immunity. DCs also control the balance between tolerance and immunity, and are required for T-cell mediated anti-tumor immunity.
Rajkumar Noubade, Sonia Majri-Morrison, Kristin V Tarbell   +2 more
exaly   +4 more sources

cDC1 to cDC2: “Everything I do, Ido1 it for you”

Immunity, 2022
Distinct dendritic cell (DC) subsets exert specific functions in immune regulation, but their communication with each other has remained elusive. In this issue of Immunity, Gargaro et al. identify the IDO1-Kyn-AHR axis as a metabolic signaling pathway through which conventional DC subsets communicate and induce tolerogenicity.
Mirja Tamara, Prentzell, Christiane A, Opitz   +1 more
openaire   +2 more sources