Results 171 to 180 of about 9,042 (190)

Doping cDC1s for tolerance

Immunity
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. propose that erythropoietin receptor signaling biases cDC1s toward a maturation state associated with ...
Victor, Bosteels, Sophie, Janssens
openaire   +2 more sources

Cryptic Activation of an Irf8 Enhancer Governs cDC1 Fate Specification [PDF]

Nature Immunology, 2019
Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction are unclear. In the present study Irf8 enhancers were identified via chromatin profiling of dendritic cells and CRISPR/Cas9 genome editing was ...
Swapneel Patel, Theresa L Murphy, Barbara L Kee   +2 more
exaly   +3 more sources

Leveraging cDC1 biology and function for enhanced immunotherapy

Journal of Experimental Medicine
Conventional type 1 dendritic cells (cDC1s) promote antitumor immunity through efficient cross-presentation of tumor antigens and production of key mediators. Crucially, in the tumor microenvironment, cDC1s orchestrate immune hubs and signaling axes that support T cell responses and are associated with improved patient outcomes.
Ross W. Ward, Uddipan Kar, Sreekumar Balan, Nina Bhardwaj   +3 more
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The Making of a cDC1 : Precision Programming of Progenitor Potential

Immunological Reviews
ABSTRACT The development of type 1 classical dendritic cells (cDC1s) from bone marrow progenitors is a multistage process directed by a complex transcriptional network. At its center is interferon regulatory factor‐8 (IRF8), the lineage‐determining factor whose precise, stage‐specific expression is integrated at ...
Theresa L. Murphy, Kenneth M. Murphy
openaire   +2 more sources

cDC1 craves glutamine for its glory

Nature Immunology, 2023
Stefania Vilbois, Jaeoh Park, Ping-Chih Ho   +2 more
openaire   +3 more sources

Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity

Science
Conventional type 1 dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8 + T cells. How tumor antigens are processed to activate CD8 + T cell immunity is not well ...
Bowen Xie, Bowen Yuan, Xiaohong Zhao, Tian Xie, Ruifeng Li, Peng Wei, Qinli Sun, Wenbo Hu, Birui Pan, Yongzhen Chen, Kun Wei, Zixuan Zhao, Lei Yuan, Xuan Zhong, Xue Bai, Qiuyan Lan, Lei Qin, Ling Ni, Chen Dong   +18 more
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CARM1: an epigenetic brake on cDC1-mediated antitumor immunity

Trends in Immunology
The underlying mechanism of tumor microenvironment-induced dysfunction of conventional type 1 dendritic cells (cDC1) remains unclear. Zhang et al. identify transforming growth factor β-driven coactivator-associated arginine methyltransferase 1 (CARM1) as an epigenetic inhibitor of cDC1 cross-presentation.
Congliang Chen, Xuetao Cao
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Faculty Opinions recommendation of cDC1 Vaccines Drive Tumor Rejection by Direct Presentation Independently of Host cDC1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2022
openaire   +1 more source

Commensal Cryptosporidium Colonization Elicits a cDC1-Dependent Th1 Response That Promotes Intestinal Homeostasis and Limits Other Infections

Immunity, 2021
Chyi-Song Hsieh, L David Sibley, Lindsey Fox   +2 more
exaly  

Mechanisms of Cross-Presentation by cDC1s

2020
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