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Science, 2020
Tumor Immunology A subset of immune cells called conventional dendritic cell 1 (cDC1) has been shown to play a critical role in antitumor responses. Hubert et al. now show that human cDC1 contribute to antitumor responses through the production of type III interferon, also known as IFN-γ1.
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Tumor Immunology A subset of immune cells called conventional dendritic cell 1 (cDC1) has been shown to play a critical role in antitumor responses. Hubert et al. now show that human cDC1 contribute to antitumor responses through the production of type III interferon, also known as IFN-γ1.
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Immunity
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. propose that erythropoietin receptor signaling biases cDC1s toward a maturation state associated with ...
Victor, Bosteels, Sophie, Janssens
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Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. propose that erythropoietin receptor signaling biases cDC1s toward a maturation state associated with ...
Victor, Bosteels, Sophie, Janssens
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IRF8 and BATF3 interaction enhances the cDC1 specific Pfkfb3 gene expression
Cellular Immunology, 2022Dendritic cells (DCs) play central role in innate as well as adaptive immune responses regulated by diverse DC subtypes that vary in terms of surface markers, transcriptional profile and functional responses. Generation of DC diversity from progenitor stage is tightly regulated by complex molecular inter-play between transcription factors.
Kuldeep Singh Chauhan +6 more
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The Making of a
ABSTRACT The development of type 1 classical dendritic cells (cDC1s) from bone marrow progenitors is a multistage process directed by a complex transcriptional network. At its center is interferon regulatory factor‐8 (IRF8), the lineage‐determining factor whose precise, stage‐specific expression is integrated at ...
Theresa L. Murphy, Kenneth M. Murphy
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Leveraging cDC1 biology and function for enhanced immunotherapy
Journal of Experimental MedicineConventional type 1 dendritic cells (cDC1s) promote antitumor immunity through efficient cross-presentation of tumor antigens and production of key mediators. Crucially, in the tumor microenvironment, cDC1s orchestrate immune hubs and signaling axes that support T cell responses and are associated with improved patient outcomes.
Ross W. Ward +3 more
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cDC1 craves glutamine for its glory
Nature Immunology, 2023Stefania Vilbois +2 more
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Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
ScienceConventional type 1 dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8 + T cells. How tumor antigens are processed to activate CD8 + T cell immunity is not well ...
Bowen Xie +18 more
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2022
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Self-antigen disrupts cDC1 mediated antitumor responses
ABSTRACT Conventional dendritic cells navigate complex tissues and sample peripheral antigens, balancing immune suppression and activation to achieve tissue homeostasis. However, it remains unclear how an individual dendritic cells reconciles co-incident signals from immunological opposing antigens within the tissue ...Victoria P Schuster +9 more
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