Results 121 to 130 of about 531,349 (289)

Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE [PDF]

Small molecule drug design hinges on obtaining co-crystallized ligand-protein structures. Despite AlphaFold2's strides in protein native structure prediction, its focus on apo structures overlooks ligands and associated holo structures. Moreover, designing selective drugs often benefits from the targeting of diverse metastable conformations. Therefore,
arxiv   +1 more source

Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. [PDF]

, 2019
Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, alone and in combination with current ...
Hackman, Robert M, Mackenzie, Gerardo G, Wang, Yuefei, Wei, Ran   +3 more
core   +1 more source

Human retinoblastoma protein (Rb) is phosphorylated by cdc2 kinase and MAP kinase in Xenopus maturing oocytes [PDF]

FEBS Letters, 1998
Xenopus oocyte meiotic maturation combines features of G0/G1 and G2/M transitions of the cell cycle. To study the in ovo Rb kinase activity, we have microinjected human Rb into oocytes. Microinjected human Rb localizes into the nucleus, is hypophosphorylated in prophase oocytes, becomes hyperphosphorylated during meiotic maturation and is ...
Taieb, Frederic, Karaiskou, A., Rime, Hélène, Jessus, Catherine   +3 more
openaire   +5 more sources

New Mechanisms and Therapeutic Targets in Systemic Lupus Erythematosus

MedComm, Volume 6, Issue 6, June 2025.
Systemic lupus erythematosus (SLE) is a multiple organ involved autoimmune disorder with heterogeneous clinical manifestations. Despite hallmark features such as elevated type I interferon and the production of numerous autoantibodies, the underlying pathogenic mechanisms remain elusive.
Jingru Tian, Hang Zhou, Wei Li, Xu Yao, Qianjin Lu   +4 more
wiley   +1 more source

The regulation of tau phosphorylation by PCTAIRE 3: Implications for the pathogenesis of Alzheimer's disease

Neurobiology of Disease, 2006
In the course of Alzheimer's disease, phosphorylated tau aggregates to form paired helical filaments, highly ordered filamentous structures that accumulate within neurons and contribute to the formation of neurofibrillary tangles. This study examines the
A.Z. Herskovits, P. Davies
doaj  

Activation of Adenosine Phosphate Signaling Promotes Antitumor Immunity in Tumor Microenvironment and Facilitate Immunotherapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
A comprehensive analysis of the purinergic signaling mediated by P2 receptors (P2Rs) was conducted at both bulk, single‐cell, and spatial transcriptomic levels, evaluating the prognostic and predictive value of the adenosine signaling pathway in cancer immunotherapy.
Yantao Xu, Ying Wang, Zixi Jiang, Yi He, Guowei Zhou, Benliang Wei, Jiachen Liu, Xiang Chen   +7 more
wiley   +1 more source

Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases [PDF]

, 2008
We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions and ...
Gil-Mi Ryu, Jong Hun Kim, Kyu-Won Kim, Kyung-Soo Oh, Pamela Song   +4 more
core   +1 more source

Molecular cloning of a novel human cdc2/CDC28-like protein kinase

Journal of Biological Chemistry, 1991
A homology probing approach was utilized to isolate a new human protein kinase. Deoxyoligonucleotide probes recognizing a conserved subdomain in the COOH-terminal portion of protein kinases identified a cDNA clone encoding a putative kinase with predicted serine/threonine phosphorylation specificity.
Kendall A. Smith, K W Johnson
openaire   +3 more sources

Physiological, genetical changes and cdc2 gene expression for osmotic stressed Vicia faba reveal the alleviation effect of gamma radiation and putrescine

Caryologia
Climate change caused increasing in soil salinity worldwide. Therefore, it is critical to enhance the capability of plant to tolerate salinity stress. For this goal, putrescine and irradiation by gamma radiation were used to improve the salt tolerance of
Shaimaa S. Sobieh, Noha Eid Eliwa
doaj   +1 more source

Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice

Frontiers in Behavioral Neuroscience, 2010
Cyclin-dependent kinase-like 2 (Cdkl2) is a cdc2-related serine/threonine protein kinase that is postnatally expressed in various brain regions, including the cerebral cortex, entorhinal cortex, hippocampus, amygdala, and dorsal thalamus.
Hiroshi Gomi, Hiroshi Gomi, Takayuki Sassa, Richard F Thomson, Shigeyoshi Itohara   +4 more
doaj   +1 more source