Results 161 to 170 of about 531,349 (289)
Animal Models and Experimental MedicineFlavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer (CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing
Mohammad Yasin Zamanian +9 more
doaj +1 more source
Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
Retrovirology, 2011 Background RNA processing plays a critical role in the replication of HIV-1, regulated in part through the action of host SR proteins. To explore the impact of modulating SR protein activity on virus replication, the effect of increasing or inhibiting ...
Dobson Wendy +5 more
doaj +1 more source
State-space modeling of dynamic genetic networks [PDF]
arXiv, 2013 The genomic reality is a highly complex and dynamic system. The recent development of high-throughput technologies has enabled researchers to measure the abundance of many genes (in the order of thousands) simultaneously. The challenge is to unravel from such measurements, gene/protein or gene/gene or protein/ protein interactions and key biological ...
arxiv
Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina [PDF]
, 2002 The laminar arrays of distinct cell types in the vertebrate retina are built by a histogenic process in which cell fate is correlated with birth order.
Harris, W.A. +4 more
core
A Monte Carlo study of ligand-dependent integrin signal initiation [PDF]
arXiv, 2010 Integrins are allosteric cell adhesion receptors that control many important processes, including cell migration, proliferation, and apoptosis. Ligand binding activates integrins by stabilizing an integrin conformation with separated cytoplasmic tails, thus enabling the binding of proteins that mediate cytoplasmic signaling.
arxiv
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance. [PDF]
, 2019 A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and ...
Jiang, Nian +3 more
core
Cell cycle regulation of p34cdc2 kinase activity in Physarum polycephalum [PDF]
, 1990 The regulation of the mitotic histone H1 kinase activity has been analyzed during the naturally synchronous cell cycle of Physarum polycephalum plasmodia.
Beach, D. +4 more
core
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities [PDF]
, 1997 Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK inhibitor SIC1. Genetic data suggest that SIC1 proteolysis is mediated by the ubiquitin pathway and requires the action of CDC34 ...
Deshaies, Raymond J. +2 more
core
SAGEPhos: Sage Bio-Coupled and Augmented Fusion for Phosphorylation Site Detection [PDF]
arXivPhosphorylation site prediction based on kinase-substrate interaction plays a vital role in understanding cellular signaling pathways and disease mechanisms. Computational methods for this task can be categorized into kinase-family-focused and individual kinase-targeted approaches.
arxiv