Results 91 to 100 of about 6,022 (190)
MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours [PDF]
, 2017 Background MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies.
Bulkowska, Malgorzata +7 more
core +1 more source
Regulation of physiological and pathological condensates by molecular chaperones
The FEBS Journal, Volume 292, Issue 13, Page 3271-3297, July 2025.Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree +5 more
wiley +1 more source
iMeta, Volume 4, Issue 3, June 2025.Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang +17 more
wiley +1 more source
Nature Communications, 2018 The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by ...
Ashleigh B. Bachman +10 more
doaj +1 more source
Overexpression of the protein kinase CK2 increases the survival and resistance to chemotherapy of acute myeloid leukemia cells [PDF]
, 2013 Background: The critical role of protein kinase CK2 in the regulation of cellular apoptosis suggests its may be involvement in tumor cell resistance to both conventional and unconventional therapies.
PAVAN, LAURA
core +1 more source
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes [PDF]
The EMBO Journal, 2002 Cdc37 has been shown to be required for the activity and stability of protein kinases that regulate different stages of cell cycle progression. However, little is known so far regarding interactions of Cdc37 with kinases that play a role in cell division. Here we show that the loss of function of Cdc37 in Drosophila leads to defects in mitosis and male
Bodo M H, Lange +3 more
openaire +2 more sources
Animal Genetics, Volume 56, Issue 3, June 2025.Abstract Identifying genomic regions under selection is crucial for comprehending the evolutionary history of the domestic chicken. Arabian Peninsula (AP) indigenous chickens are mostly found outdoors, being reared alongside other livestock for production purposes.
Abdulwahad Assiri +9 more
wiley +1 more source
Advanced Science, Volume 12, Issue 13, April 3, 2025.The study shows that RPAP2, acting as an oncoprotein, promotes hepatocellular carcinoma (HCC) progression, with its stability being negatively regulated by FBXW7, yet positively by HSP90 and USP7. The FBXW7‐RPAP2 axis plays a crucial role in controlling HCC cell growth and influencing liver cell differentiation.
Danrui Cui +14 more
wiley +1 more source
Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation
Stem Cell Reports, 2018 Summary: Neural stem cells (NSCs) have the ability to exit quiescence and reactivate in response to physiological stimuli. In the Drosophila brain, insulin receptor (InR)/phosphatidylinositol 3-kinase (PI3K)/Akt pathway triggers NSC reactivation. However,
Jiawen Huang, Hongyan Wang
doaj +1 more source
Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt) [PDF]
, 2017 Natural ingredients are valuable options to be exploited in the design of innovative food formulations with health benefits. Therefore, it was evaluated the potential use of Arenaria montana L.
Abreu, Rui M.V. +8 more
core +1 more source