Results 61 to 70 of about 6,022 (190)
Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction [PDF]
Journal of Biological Chemistry, 2009 The molecular chaperone heat shock protein 90 (Hsp90) is required for the stabilization and conformational maturation of various oncogenic proteins in cancer. The loading of protein kinases to Hsp90 is actively mediated by the cochaperone Cdc37. The crucial role of the Hsp90-Cdc37 complex has made it an exciting target for cancer treatment.
Tao, Zhang +5 more
openaire +2 more sources
Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
Scientific Reports, 2022 The HSP90/CDC37 chaperone system not only assists the maturation of many protein kinases but also maintains their structural integrity after folding.
Marco Papenfuss +6 more
doaj +1 more source
Antiangiogenic compounds: well-established drugs versus emerging natural molecules [PDF]
, 2018 Angiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a ...
Abreu, Rui M.V. +4 more
core +1 more source
Role of p50/CDC37 in Hepadnavirus Assembly and Replication [PDF]
Journal of Biological Chemistry, 2002 The cellular chaperone Hsp90 has been shown to associate with the reverse transcriptase (RT) of the duck hepatitis B virus and is required for RT functions. However, the molecular basis for the specific interaction between the RT and Hsp90 remains unknown.
Xingtai, Wang +2 more
openaire +2 more sources
, 2006 Cyclin-dependent kinase (CDK)4 is a master integrator that couples mitogenic and antimitogenic extracellular signals with the cell cycle. It is also crucial for many oncogenic transformation processes.
Laurence Bockstaele +4 more
core +2 more sources
Cdc37 Promotes the Stability of Protein Kinases Cdc28 and Cak1 [PDF]
Molecular and Cellular Biology, 2000 In the budding yeast Saccharomyces cerevisiae, Cdc37 is required for the productive formation of Cdc28-cyclin complexes. The cdc37-1 mutant arrests at Start with low levels of Cdc28 protein, which is predominantly unphosphorylated at Thr169, fails to bind cyclin, and has little protein kinase activity.
A, Farrell, D O, Morgan
openaire +2 more sources
Systematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT2. [PDF]
PLoS ONE, 2013 AKT2 is one of the three isoforms of the protein kinase AKT being involved in the modulation of cellular metabolism. Since protein-protein interactions are one possibility to convey specificity in signal transduction, we performed AKT2-protein ...
Katharina Bottermann +4 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2021 Cell division cycle 37 (Cdc37) is an important cytoplasmic phosphoprotein, which usually functions as a complex with heat shock protein 90 (Hsp90), to effectively reduce the damage caused by heavy metals, such as cadmium (Cd), in aquatic animals.
Chao Zhao +5 more
doaj +1 more source
Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. [PDF]
, 2015 Thermal exposure is a serious and growing challenge facing fish species worldwide. Chinook salmon (Oncorhynchus tshawytscha) living in the southern portion of their native range are particularly likely to encounter warmer water due to a confluence of ...
Baerwald, Melinda R +6 more
core
Characterization of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata [PDF]
, 2016 HSP90 chaperones are essential regulators of cellular function, as they ensure the appropriate conformation of multiple key client proteins. Four HSP90 isoforms were identified in the protozoan parasite Theileria annulata.
Calder, Ewen D.D. +8 more
core +2 more sources