Results 71 to 80 of about 6,022 (190)

Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review comprehensively analyses the phytochemicals from Eclipta prostrata, identifying 25 active compounds with chemotherapeutic potential against 15 different human malignancies. These compounds modulate diverse and complex mechanisms, including targeting critical signaling pathways (e.g., PI3K/AKT/mTOR), inducing regulated cell death (e.g., FAS,
Md. Sakhawat Hossain, Sanzida Khatun, Md Mojnu Mia, Fatematuz Zohora, Md. Rifat Sarker, K. M. Tanjida Islam, Md. Abu Sayeed, Moushumi Afroza Mou, Sherif Hamidu, Fatima Hamidu, A. M. Wasaf Hasan, Sanjida Mumtaj, Md Khaled Hossain, Md Sohel   +13 more
wiley   +1 more source

SCAND1 suppresses CDC37 gene transcription by repressing MZF1 [PDF]

, 2019
AbstractCDC37 increases the stability of HSP90 client proteins and is essential for numerous intracellular oncogenic signaling pathways. Elevated expression of CDC37 was found in prostate cancer cells, although the regulatory mechanisms through which CDC37 expression becomes increased are unknown.
Eguchi, Takanori, Prince, Thomas L., Tran, Manh Tien, Sogawa, Chiharu, Lang, Benjamin J., Calderwood, Stuart K.   +5 more
openaire   +1 more source

Renoprotective Role and Mechanisms of Luteolin in Chronic Kidney Disease: Insights From NHANES Data, Network Pharmacology, Mendelian Randomization, and Molecular Docking Techniques

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study identified luteolin as a key flavonoid linked to lower CKD risk. Mediation analysis indicated that lower systemic inflammation, reduced serum uric acid, and higher bicarbonate and albumin levels collectively account for part of this relationship.
Mengjin Li, Kai Hu, Juan Chen, Xinming Li, Cheng Xue, Zhiguo Mao   +5 more
wiley   +1 more source

Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells

Exploration of Medicine
Aim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome.
Jayasree Santhanakrishnan, Prabhu Meganathan, Hemamalini Vedagiri   +2 more
doaj   +1 more source

AUY922 induces retinal toxicity through attenuating TRPM1

Journal of Biomedical Science, 2021
Background Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal toxicity remain undescribed ...
Che-Hung Shen, Chi-Che Hsieh, Kuan-Ying Jiang, Chih-Yu Lin, Nai-Jung Chiang, Ting-Wei Li, Chun-Ting Yen, Wan-Ju Chen, Daw-Yang Hwang, Li-Tzong Chen   +9 more
doaj   +1 more source

Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy [PDF]

Molecular Cell, 2011
Autophagy, the primary recycling pathway of cells, plays a critical role in mitochondrial quality control under normal growth conditions and in the response to cellular stress. The Hsp90-Cdc37 chaperone complex coordinately regulates the activity of select kinases to orchestrate many facets of the stress response.
Joo, Joung Hyuck, Dorsey, Frank C., Joshi, Aashish, Hennessy-Walters, Kristin M., Rose, Kristie L., McCastlain, Kelly, Zhang, Ji, Iyengar, Rekha, Jung, Chang Hwa, Suen, Der-Fen, Steeves, Meredith A., Yang, Chia-Ying, Prater, Stephanie M., Kim, Do-Hyung, Thompson, Craig B., Youle, Richard J., Ney, Paul A., Cleveland, John L., Kundu, Mondira   +18 more
openaire   +2 more sources

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, Volume 58, Issue 12, December 2025.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

The mammalian ULK1 complex and autophagy initiation [PDF]

, 2017
Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the cell.
Bach, Bento, Chan, Chan, Chauhan, Chen, Cheong, Chude, Di Bartolomeo, Dunlop, Egan, Egan, Farre, Fullgrabe, Gammoh, Gan, Gan, Ganley, Henckaerts, Hieke, Hosokawa, Hosokawa, Ian G. Ganley, Itakura, James T. Murray, Jiang, Jon D. Lane, Joo, Jung, Kaizuka, Kaizuka, Karanasios, Karanasios, Kim, Konno, Koyama-Honda, Kundu, Lamark, Lazarou, Lazarus, Lee, Li, Li, Li, Li, Lim, Lin, Lin, Liu, Liu, Maria Zachari, McWilliams, Mercer, Nazio, Nazio, Ochaba, Orsi, Pengo, Petherick, Pickrell, Pike, Puente, Puri, Qi, Rabanal-Ruiz, Rui, Russell, Sarraf, Schneider, Sellier, Su, Sun, Suzuki, Tian, Torii, Ugolino, Viktor I. Korolchuk, Wang, Webster, Wold, Wong, Wu, Xu, Yang, Young, Yun, Zhou, Zou   +87 more
core   +2 more sources

Cdc37 as a Co-chaperone to Hsp90 [PDF]

, 2014
The co-chaperone p50/Cdc37 is an important partner for Hsp90, assisting in molecular chaperone activities, particularly with regard to the regulation of protein kinases. The Hsp90/Cdc37complex controls the folding of a large proportion of protein kinases and thus stands at the hub of a multitude of intracellular signaling networks.
openaire   +2 more sources

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source