Results 101 to 110 of about 75,568 (261)
Cdc42 in oncogenic transformation, invasion, and tumorigenesis [PDF]
Cellular Signalling, 2011 The Rho family of GTPases represents a class of Ras-related signaling molecules often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP-bound, active state in response to extracellular stimuli such as mitogens and extracellular matrix.
Kristy, Stengel, Yi, Zheng
openaire +2 more sources
iNew Medicine, EarlyView.ABSTRACT High‐grade serous ovarian cancer (HGSOC) is the most common and lethal histological subtype of ovarian cancer. This study aimed to identify peritoneal metastasis‐associated biomarkers of HGSOC to provide directions for subsequent treatment. Transcriptome data were extracted from the GEO database and literature. Differential expression analysis,
Jing Zhu +8 more
wiley +1 more source
Relation of CDC42, Th1, Th2, and Th17 cells with cognitive function decline in Alzheimer's disease
Annals of Clinical and Translational Neurology, 2022 Objective Cell division cycle 42 (CDC42) regulates neurite outgrowth, neurotransmitter, and T help (Th) cell‐mediated neuroinflammation, while its clinical implication in Alzheimer's disease (AD) is not clear.
Yi Zhang, Chenglin Niu
doaj +1 more source
Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]
, 2004 Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM +8 more
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito +11 more
wiley +1 more source
Insights into the origin of metazoan filopodia and microvilli. [PDF]
, 2013 Filopodia are fine actin-based cellular projections used for both environmental sensing and cell motility, and they are essential organelles for metazoan cells. In this study, we reconstruct the origin of metazoan filopodia and microvilli.
Burkhardt, Pawel +6 more
core +2 more sources
α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions [PDF]
, 2021 Jake Davey Howden +3 more
openalex +1 more source
Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein
Developmental Biology, 2013 Fibroblast growth factor (FGF) signaling is required for numerous aspects of neural development, including neural induction, CNS patterning and neurogenesis. The ability of FGFs to activate Ras/MAPK signaling is thought to be critical for these functions.
Hulstrand, Alissa M. +1 more
openaire +2 more sources
Phytotherapy Research, EarlyView.Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam +14 more
wiley +1 more source
Opposing Expressions of Nidogen-1 and Cdc42 Genes in the Development of Liver Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease [PDF]
پزشکی بالینی ابن سیناBackground and Objective: The roles of Nidogen-1 and Cdc42 genes as significant factors in the metabolism of the extracellular matrix have been demonstrated in the fibrosis of various tissues. This study investigates the gene expressions of Nidogen-1 and
Zahra Ali +2 more
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