Results 101 to 110 of about 81,267 (316)

The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway [PDF]

, 2009
© 2009 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Höfken, Thomas, Jacquier, Nicolas, Just, Ursula, Lin, Meng, Schneiter, Roger, Unden, Heike   +5 more
core   +2 more sources

Inhibition of Cdc42–intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth

Cancer Biology & Therapy, 2019
Cdc42 is a member of the Rho family of small GTPases that are at the crossroads of major oncogenic signaling pathways involved in both lung and prostate cancers.
Byron J. Aguilar, Yaxue Zhao, Huchen Zhou, Shouquan Huo, Yan-hua Chen, Q. Lu   +5 more
semanticscholar   +1 more source

Biomimetic Microstructured Scaffold with Release of Re‐Modified Teriparatide for Osteoporotic Tendon‐to‐Bone Regeneration via Balancing Bone Homeostasis

Advanced Science, EarlyView.
This study develops RPTH by re‐modifying teriparatide and designs a biomimetic microstructured scaffold (BMRP) loaded with RPTH to address osteoporotic tendon‐to‐bone interface repair. The BMRP restores tissue architecture by balancing bone homeostasis and remodeling the microstructure, achieving functional recovery in an osteoporotic rotator cuff tear
Chengzhong Xu, Sijie Qiu, Zhigen Yuan, Chongyin Qiu, Wenyu Xu, Jialiang Guo, Gen Wen, Shuai Liu, Wenjuan Yan, Haibing Xu, Honghao Hou, Dehong Yang   +11 more
wiley   +1 more source

Effects of cdc42 gene knockout by CRISPR/Cas9 technology on osteochondral development in zebrafish

陆军军医大学学报
Objective To knock out cdc42 gene in zebrafish using CRISPR/Cas9 technology, and investigate the effect of cdc42 on early osteochondral development.
YANG Yunfei, LI Yi, SUN Xianding
doaj   +1 more source

Cdc42 Couples T Cell Receptor Endocytosis to GRAF1-Mediated Tubular Invaginations of the Plasma Membrane

Cells, 2019
: T cell activation is immediately followed by internalization of the T cell receptor (TCR). TCR endocytosis is required for T cell activation, but the mechanisms supporting removal of TCR from the cell surface remain incompletely understood.
Pascal Rossatti, Luca Ziegler, Richard Schregle, Verena M Betzler, Manuela Ecker, Jérémie Rossy   +5 more
doaj   +1 more source

Relation of CDC42, Th1, Th2, and Th17 cells with cognitive function decline in Alzheimer's disease

Annals of Clinical and Translational Neurology, 2022
Objective Cell division cycle 42 (CDC42) regulates neurite outgrowth, neurotransmitter, and T help (Th) cell‐mediated neuroinflammation, while its clinical implication in Alzheimer's disease (AD) is not clear.
Yi Zhang, Chenglin Niu
doaj   +1 more source

Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates

Molecules, 2018
Despite great improvements in the diagnosis and treatment of neoplasms, metastatic disease is still the leading cause of death in cancer patients, with mortality rates still rising.
Xing-Hua Xiao, Lin-Chen Lv, Jing Duan, Yemeng Wu, Shu-Jin He, Zhen-Zhen Hu, Li-Xia Xiong   +6 more
semanticscholar   +1 more source

Spatial analysis of Cdc42 activity reveals a role for plasma membrane–associated Cdc42 in centrosome regulation

Molecular Biology of the Cell, 2017
The ability of the small GTPase Cdc42 to regulate diverse cellular processes depends on tight spatial control of its activity. Cdc42 function is best understood at the plasma membrane (PM), where it regulates cytoskeletal organization and cell polarization. Active Cdc42 has also been detected at the Golgi, but its role and regulation at this organelle
Klaus M. Hahn, Christine Sütterlin, Carolyn Dang, Enrico Gratton, Enrico Gratton, Andrew L. Trinh, Ellen C. O’Shaughnessy, Kari A. Herrington, Michelle A. Digman, Michelle A. Digman   +9 more
openaire   +4 more sources

Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia

Clinical and Translational Medicine, 2017
Background Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic lethality with heart developmental
Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong, Xu Peng   +7 more
doaj   +1 more source

CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes

BMC Biology, 2018
In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance of the reproductive lifespan. Misregulated activation of primordial follicles leads to various ovarian diseases, such as premature ...
Hao Yan, Jiawei Zhang, Jia Wen, Yibo Wang, Wanbao Niu, Zhen Teng, Tong Zhao, Yanli Dai, Yan Zhang, Chao Wang, Y. Qin, G. Xia, Hua Zhang   +12 more
semanticscholar   +1 more source