Rac1 and Cdc42 but Not RhoA or Rho Kinase Activities Are Required for Neurite Outgrowth Induced by the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) in N1E-115 Neuroblastoma Cells [PDF]
, 2002 Xiaodong Li +3 more
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Cdc42 activity in the trailing edge is required for persistent directional migration of keratinocytes [PDF]
, 2023 Rutuja Patwardhan +5 more
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MedComm, Volume 6, Issue 11, November 2025.This review systematically summarizes dendritic cells (DCs) originating from hematopoietic stem cells, their major subsets (cDC1s, cDC2s, pDCs, moDCs, LCs) and core functions (antigen capture/presentation, adaptive immunity activation, immune tolerance induction, and regulation of innate immune cells).
Fangfang Jin +7 more
wiley +1 more source
A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation [PDF]
, 2000 Rongguo Qiu, Arie Abo, Greg S. Martin
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ROS‐Driven PKCζ Signaling as a Widely Involved Mechanism for Cancer Cell Motility and Metastasis
Cancer Science, Volume 116, Issue 11, Page 3027-3039, November 2025.This study reveals that the enhancement of cancer cell motility by diverse bioactive molecules—including growth factors, hormones, and tissue factors—is mediated through a common intracellular mechanism involving reactive oxygen species (ROS) and the PKCζ/Rho GTPase signaling pathway.
Yasushi Sato +9 more
wiley +1 more source
Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells [PDF]
, 2007 Christian Frantz +4 more
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Neocortical neurogenesis: a proneural gene perspective
The FEBS Journal, Volume 292, Issue 21, Page 5580-5610, November 2025.The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan +3 more
wiley +1 more source
Low Expression of FGD3, a Putative Guanine Nucleotide Exchange Factor for CDC42, is Prognostic of Poor Outcome in Breast Cancer [PDF]
, 2014 Scooter Willis +3 more
openalex +1 more source