Learning Information Spread in Content Networks
, 2013 We introduce a model for predicting the diffusion of content information on social media. When propagation is usually modeled on discrete graph structures, we introduce here a continuous diffusion model, where nodes in a diffusion cascade are projected ...
Bourigault, Simon +4 more
core +2 more sources
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Immunomodulation as a Potent COVID-19 Pharmacotherapy: Past, Present and Future
Journal of Inflammation Research, 2021 Decsa Medika Hertanto,1,2 Bayu Satria Wiratama,3,4 Henry Sutanto,5,6 Citrawati Dyah Kencono Wungu7,8 1Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; 2Department of Internal Medicine, Dr.
Hertanto DM +3 more
doaj
Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling [PDF]
, 2020 Maria C. Tanzer +4 more
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Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
Journal of Intelligent Medicine, EarlyView.Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan +3 more
wiley +1 more source
Integrative multi-omics analysis reveals the landscape of Cyclin-Dependent Kinase (CDK) family genes in pan-cancer [PDF]
, 2022 Peng Wang +4 more
openalex +1 more source
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, EarlyView.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Taxonomic insights into Indian Rotala (Lythraceae) species with verticillate phyllotaxy
Nordic Journal of Botany, EarlyView.In an effort to resolve taxonomic complexities among Indian Rotala species with verticillate phyllotaxy, this study provides an identification key, revised nomenclature, updated morphological descriptions including SEM studies of seed coat surfaces, detailed photoplates, and notes on phenology, ecology, and distribution.
Arikrishnan Parthiban +2 more
wiley +1 more source
G1/S CDK is inhibited to restrain mitotic onset when DNA replication is blocked in fission yeast [PDF]
, 2002 Patrick Zarzov
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