Results 111 to 120 of about 125,522 (281)

Data from Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non–Small Cell Lung Cancer

, 2023
Chellappagounder Thangavel, Ettickan Boopathi, Yi Liu, Christopher McNair, Alex Haber, Maryna Perepelyuk, Anshul Bhardwaj, Sankar Addya, Adam Ertel, Sunday Shoyele, Ruth Birbe, Joseph M. Salvino, Adam P. Dicker, Karen E. Knudsen, Robert B. Den   +14 more
openalex   +1 more source

Cell Cycle Control by Xenopus p28^(Kix1) a Developmentally Regulated Inhibitor of Cyclin-dependent Kinases [PDF]

, 1996
We have isolated Xenopus p28^(Kix1), a member of the p21^(CIP1)/p27^(KIP1)/p57^(KIP2) family of cyclin-dependent kinase (Cdk) inhibitors. Members of this family negatively regulate cell cycle progression in mammalian cells by inhibiting the activities of
Dunphy, William G., Shou, Wenying
core  

Exploration of Therapeutic Targets Using CDK4 Inhibitors for Head and Neck Mucosal Melanoma

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Mucosal melanoma (MM) is an extremely aggressive malignant tumor in the head and neck region associated with a poor prognosis. In the present study, we conducted cell proliferation assay and western blotting using cell lines derived from MM and the immunohistochemical analysis of pathological MM tissues to identify novel therapeutic ...
Takayoshi Hattori, Makiko Fujii, Tsutomu Ueda, Akira Ishikawa, Yuichi Mine, Bingwen Xu, Tomoya Suehiro, Minoru Hattori, Hiroaki Tahara, Yuki Sato, Nobuyuki Chikuie, Takayuki Taruya, Takao Hamamoto, Takashi Ishino, Sachio Takeno   +14 more
wiley   +1 more source

Not Just a CDK Inhibitor: Regulation of Transcription by p21^{WAF1/CIP1/SDI1} [PDF]

, 2002
Neil D. Perkins
openalex   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6 [PDF]

, 1997
Leslie R. Morse, Dongquan Chen, David Franklin, Yue Xiong, Selina Chen‐Kiang   +4 more
openalex   +1 more source

Minkowski content and fractal curvatures of self-similar tilings and generator formulas for self-similar sets [PDF]

, 2014
We study Minkowski contents and fractal curvatures of arbitrary self-similar tilings (constructed on a feasible open set of an IFS) and the general relations to the corresponding functionals for self-similar sets.
Winter, Steffen
core  

GraphReco: Probabilistic Structure Recognition for Chemical Molecules

ChemistryOpen, EarlyView.
Molecule structure images are unfriendly for machine understanding, blocking productivity improvements in chemical data mining, drug discovery, and many other fields. We present a rule‐based probabilistic Optical Chemical Structure Recognition model to explain and tackle the ambiguity challenges in graph assembly.
Haidong Wang, Yuncheng Yu, Jyh‐Charn Liu   +2 more
wiley   +1 more source

New Roots for Restoration: Building a foundation for interdisciplinary work in plant organismal biology and ecology to advance restoration in natural and agricultural ecosystems

PLANTS, PEOPLE, PLANET, EarlyView.
Soils are globally degraded due in part to conventional agriculture and wildland conversion. To address the global challenge of soil degradation, we formed an interdisciplinary, cross‐institutional collaborative research team, New Roots for Restoration, to understand how perennial plant root and shoot traits relate to one another, and how they ...
Alicia J. Foxx, Sandra Arango‐Caro, James D. Bever, Keely Elizabeth Brown, Kristine L. Callis‐Duehl, Louise Egerton‐Warburton, Noah Fahlgren, Malia Gehan, Molly Hanlon, Ruth J. Kaggwa, Andrea Kramer, Tiffany Langewisch, Tom McKenna, Leila Rquibi, Ben Sikes, Aubrey Streit Krug, Abby Stylianou, Laura van der Pol, Liz Vogel, Eric Von Wettberg, Jacob Zeldin, Nyree Zerega, Maya Allen, Jackson Braley, Austin Carnahan, Timothy E. Crews, Madeline DuBois, Maddie Earnest, Martel Ellis, Kevin Haggerty, Hannah Hemmelgarn, Bailey Kretzler, Nolan Monaghan, Laura Y. Podzikowski, Karen Schmiedeler, Peggy Schultz, Luke Shimabukuro, Isabella Vergara, Maggie Wagner, Rachel Warner, Gregory Ziegler, Kayri Havens, Ivan Baxter, Allison Miller   +43 more
wiley   +1 more source

Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner [PDF]

, 2002
Dimitri Lodygin, Antje Menssen, Heiko Hermeking   +2 more
openalex   +1 more source