Results 111 to 120 of about 138,770 (367)
CDK activity provides temporal and quantitative cues for organizing genome duplication. [PDF]
PLoS Genetics, 2018 In eukaryotes, the spatial and temporal organization of genome duplication gives rise to distinctive profiles of replication origin usage along the chromosomes.
Anthony Perrot +4 more
doaj +1 more source
Weighted Contrastive Divergence [PDF]
, 2018 Learning algorithms for energy based Boltzmann architectures that rely on gradient descent are in general computationally prohibitive, typically due to the exponential number of terms involved in computing the partition function.
Castrillejo, Ferran Mazzanti +3 more
core +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims Clinical guidelines for breast cancer management have evolved in the past decade. However, limited evidence exists regarding uptake of novel drug classes in management of hormone receptor‐positive (HR+) metastatic breast cancer (MBC) in the USA and whether disparities exist by race and ethnicity.
Kexin Zhu +4 more
wiley +1 more source
A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan [PDF]
, 2008 A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent ...
Ali, Reza +7 more
core +1 more source
Consequences of abnormal CDK activity in S phase [PDF]
Cell Cycle, 2016 Cyclin Dependent Kinases (CDKs) are important regulators of DNA replication. In this work we have investigated the consequences of increasing or decreasing the CDK activity in S phase. To this end we identified S-phase regulators of the fission yeast CDK, Cdc2, and used appropriate mutants to modulate Cdc2 activity.
Beáta Grallert +3 more
openaire +3 more sources
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
CDK contribution to DSB formation and recombination in fission yeast meiosis.
PLoS Genetics, 2019 CDKs (cyclin-dependent kinases) associate with different cyclins to form different CDK-complexes that are fundamental for an ordered cell cycle progression, and the coordination of this progression with different aspects of the cellular physiology ...
Luisa F Bustamante-Jaramillo +5 more
doaj +1 more source
The p53-MDM2 network: from oscillations to apoptosis [PDF]
, 2007 The p53 protein is well-known for its tumour suppressor function. The p53-MDM2 negative feedback loop constitutes the core module of a network of regulatory interactions activated under cellular stress.
Bose, Indrani, Ghosh, Bhaswar
core +2 more sources
Involvement of cdks and cyclins in muscle differentiation.
European journal of histochemistry : EJH, 2006 Myocyte differentiation is due to transcription of genes that characterize the phenotypic and biochemical identity of differentiated muscle cells. These are the myogenic regulatory factors (MRFs) MyoD, Myf5, myogenin and MRF4. Overexpression of cdk/cyclins has been reported to inhibit the activity of MyoD and prevent myogenic differentiation by ...
DE FALCO M, DE LUCA, Antonio
openaire +6 more sources
Chemistry &Biodiversity, EarlyView.ABSTRACT Chemical investigation of Disynaphia filifolia (Hassl.) R.M. King & H. Rob. (Asteraceae) led to the isolation of eight compounds, with tremetone being the major metabolite recovered. Tremetone has been suggested as the toxic compound in Ageratina altissima and Isocoma pluriflora, two species of the Asteraceae family. Although D.
Yasmin Rodrigues Chierici +11 more
wiley +1 more source