Results 241 to 250 of about 138,770 (367)

A comprehensive review on computational metabolomics: Advancing multiscale analysis through <i>in-silico</i> approaches. [PDF]

Comput Struct Biotechnol J
Nafie MS, Abu-Elsaoud AM, Diab MK.
europepmc   +1 more source

Differential regulation of the CDK inhibitor p27 (KIP1) following CCL4 induced liver injury

, 2000
Angela L. Tyner, Young Hye Kwon, Hiroaki Kiyokawa, Michael S. Serfas   +3 more
openalex   +1 more source

CDK Inhibitor p18INK4c Is Required for the Generation of Functional Plasma Cells [PDF]

, 2002
Michelle R. Tourigny, Josie Ursini‐Siegel, Hayyoung Lee, Kai‐Michael Toellner, Adam F. Cunningham, David S. Franklin, Scott Ely, Meihong Chen, F. Xiao‐Feng Qin, Yue Xiong, Ian C. M. MacLennan, Selina Chen‐Kiang   +11 more
openalex   +1 more source

Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors

Cell Cycle, 2015
N. Bendris, B. Lemmers, J. Blanchard
semanticscholar   +1 more source

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan, Yu Zhang, Guohua Mao, Jun Yu, Tianxing Zhou, Jihui Hao   +5 more
wiley   +1 more source

Erratum to “CDK-inhibitor olomucine inhibits cell death after exposure of cell lines to cytosine-arabinoside” [Cancer Lett. 138 (1999) 221–226]

, 2000
Konstantinos Papazisis, George D. Geromichalos, Demetrios Kouretas, Konstantinos Dimitriadis, Alexander H. Kortsaris   +4 more
openalex   +1 more source

ARABIDOPSIS HOMOLOG OF TRITHORAX1 impacts lateral root development by epigenetic regulation of targets involved in root system architecture

New Phytologist, Volume 247, Issue 5, Page 2180-2195, September 2025.
Summary Developmental processes are regulated at multiple levels, including the epigenetic level. Among the epigenetic factors, histone H3 lysine 4 (H3K4) methyltransferases contribute to active transcription of target genes, and here, we explored how the H3K4 methyltransferase ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1) affects Arabidopsis thaliana ...
Selene Napsucialy‐Mendivil, Héctor H. Torres‐Martínez, Gustavo Rodríguez‐Alonso, Diana Marcela Rivera‐Toro, Raúl Alvarez‐Venegas, Marco Adán Júarez‐Verdayes, Svetlana Shishkova, Joseph G. Dubrovsky   +7 more
wiley   +1 more source

Hallmarks and mechanisms of cellular senescence in aging and disease. [PDF]

Cell Death Discov
Ajoolabady A, Pratico D, Bahijri S, Eldakhakhny B, Tuomilehto J, Wu F, Ren J.   +6 more
europepmc   +1 more source

The Proto-oncogene c-myc Acts through the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1to Facilitate the Activation of Cdk4/6 and Early G1Phase Progression [PDF]

, 2002
Álvaro J. Obaya, Iulia Kotenko, Michael D. Cole, John M. Sedivy   +3 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, Volume 19, Issue 8, Page 2412-2430, August 2025.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source