Results 251 to 260 of about 138,770 (367)

Hallmarks of cellular senescence: biology, mechanisms, regulations. [PDF]

Exp Mol Med
Ajoolabady A, Pratico D, Bahijri S, Tuomilehto J, Uversky VN, Ren J.   +5 more
europepmc   +1 more source

Podocyte expression of the CDK-inhibitor p57 during development and disease

, 2001
Keiju Hiromura, Leah A. Haseley, Pumin Zhang, Toshiaki Monkawa, Raghu Durvasula, Arndt T. Petermann, Charles E. Alpers, Peter Mündel, Stuart J. Shankland   +8 more
openalex   +1 more source

Not Just a CDK Inhibitor: Regulation of Transcription by p21^{WAF1/CIP1/SDI1} [PDF]

, 2002
Neil D. Perkins
openalex   +1 more source

The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts

EMBO Journal, 1999
M. Cheng, P. Olivier, J. Diehl, M. Fero, M. Roussel, James M. Roberts, C. Sherr   +6 more
semanticscholar   +1 more source

A sejtek osztódásának aktiválásában és szabályozásában szerepet játszó fehérjék lucernában [PDF]

, 2008
Miskolczi Pál
core  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, Volume 19, Issue 8, Page 2292-2309, August 2025.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, Volume 19, Issue 8, Page 2212-2232, August 2025.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing. [PDF]

Nat Commun
Ng HY, Whelpley DH, Adly AN, Maxwell RA, Morgan DO.   +4 more
europepmc   +1 more source

Immunohistochemical Expression of Cell Cycle Proteins E2F-1, Cdk-2, Cyclin E, p27kip1, and Ki-67 in Normal Placenta and Gestational Trophoblastic Disease

, 2001
Maria Olvera, S. Harris, Charles A. Amezcua, Althea McCourty, Sherif Rezk, Charles Koo, Janine F. Felix, Russell K. Brynes   +7 more
openalex   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, Volume 19, Issue 8, Page 2174-2195, August 2025.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source