Results 61 to 70 of about 138,770 (367)

The Role of CDKs and CDKIs in Murine Development [PDF]

International Journal of Molecular Sciences, 2020
Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are essential for appropriate embryonic development. The twenty known mouse CDKs and eight CDKIs have been studied to varying degrees in the developing mouse, but only a ...
Campbell, Grace Jean, Hands, Emma Langdale, Van De Pette, Mathew   +2 more
openaire   +2 more sources

Ubiquitin ligase activity inhibits Cdk5 to control axon termination.

PLoS Genetics, 2022
The Cdk5 kinase plays prominent roles in nervous system development, plasticity, behavior and disease. It also has important, non-neuronal functions in cancer, the immune system and insulin secretion.
Muriel Desbois, Karla J Opperman, Jonathan Amezquita, Gabriel Gaglio, Oliver Crawley, Brock Grill   +5 more
doaj   +1 more source

The cyclin-dependent kinase inhibitor Orysa;KRP1 plays an important role in seed development of rice [PDF]

, 2006
Kip-related proteins (KRPs) play a major role in the regulation of the plant cell cycle. We report the identification of five putative rice (Oryza sativa) proteins that share characteristic motifs with previously described plant KRPs.
Barrôco, Rosa Maria, Beemster, Gerrit, Broekaert, Willem F, De Veylder, Lieven, De Wolf, Joris, Droual, Anne-Marie, Frankard, Valerie, Inzé, Dirk, Mironov, Vladimir, Nguyen, Long, Peerbolte, Rindert, Peres, Adrian   +11 more
core   +3 more sources

Regulating S Phase: CDKs, Licensing and Proteolysis [PDF]

Cell, 1996
The above model explains how reformation of initiation complexes is prevented by CDK activity. However, it does not explain how activated replication complexes bound to the DNA are inactivated once they have completed replication. Although the ORC proteins themselves remain constant in level during the cell cycle, the Cdc6/cdc18 class of protein drops ...
Paul Nurse, Jérôme Wuarin
openaire   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Expression of cyclin-dependent kinases and their clinical significance with immune infiltrates could predict prognosis in colorectal cancer

Biotechnology Reports, 2021
Introduction: Colorectal cancer (CRC) is one of the most cancer-related mortalities worldwide and remains a major public health issue. Despite several attempts to develop promising therapies for CRC, its survival rate decreases with metastasis.
Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Olalekan Olanrewaju Bakare, Ashwil Klein, Abram Madimabe Madiehe, Mervin Meyer   +5 more
doaj  

Study on the interaction preference between CYCD subclass and CDK family members at the poplar genome level

Scientific Reports, 2022
Cyclin-dependent kinases (CDKs) control the progression of the cell cycle. D-type cyclin (CYCD) is generally believed to form a complex with CDK and control the G1/S transition.
Chengcheng He, Jinghui Liang, Zhaoqun Wu, Xianglin Zhuge, Nan Xu, Hailing Yang   +5 more
doaj   +1 more source

T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue [PDF]

, 2007
As in other eukaryotes, progression through the cell cycle in plants is governed by cyclin-dependent kinases. Phosphorylation of a canonical Thr residue in the T-loop of the kinases is required for high enzyme activity in animals and yeast.
, Dissmeyer, N., Grini, P., Inzé, D., Nowack, M., Pusch, S., Schnittger, A., Stals, H.   +7 more
core   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Integrated analysis of microRNA expression in tears of Kazakh patients with climatic droplet keratopathy in Xinjiang, China

Heliyon, 2023
Climatic droplet keratopathy (CDK) is a corneal diseases, which is characterized by increased oil-like deposits on the anterior elastic lamina and anterior stromal layer. Severe CDK can even cause blindness, with no specific available treatment. Besides.
Zhixiang Hua, Xiaoyan Han, Guoqing Li, Li Lv, Nuerguli Jianimuhan, Dongmei Ma, Lei Cai, Fangyuan Hu, Jin Yang   +8 more
doaj