Results 71 to 80 of about 138,770 (367)
The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. [PDF]
Overexpression and/or hyperactivation of cyclin-dependent kinases (CDKs) are common features of most cancer types. CDKs have been shown to play important roles in tumor cell proliferation and growth by controlling cell cycle, transcription, and RNA ...
Duan, Zhenfeng+4 more
core +1 more source
Cdks put Treslin on TopBP1 [PDF]
![Figure][1] DNA synthesis (indicated by green nuclei) occurs in cells expressing wild-type Treslin (left) but not in cells expressing a nonphosphorylatable version of the protein (right).
openaire +2 more sources
Evidence for CDK-Dependent and CDK-Independent Functions of the Murine Gammaherpesvirus 68 v-Cyclin [PDF]
ABSTRACT Gamma-2 herpesviruses encode homologues of mammalian D-type cyclins (v-cyclins), which likely function to manipulate the cell cycle, thereby providing a cellular environment conducive to virus replication and/or reactivation from latency.
Jason W. Upton+2 more
openaire +3 more sources
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi+12 more
wiley +1 more source
Chronic Kidney Disease (CKD) Diagnosis using Machine Learning Methodology Classifications
Early diagnosis of kidney as well as pre-kidney disease is crucial for patients because it allows them to take control of their condition and could potentially avoid or delay more significant consequences that could lower their quality of life.
Ahmed Sami Jaddoa
doaj +1 more source
Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. [PDF]
Cell proliferation and differentiation are regulated in a highly coordinated and inverse manner during development and tissue homeostasis. Terminal differentiation usually coincides with cell cycle exit and is thought to engage stable transcriptional ...
Jerome Korzelius+9 more
doaj +1 more source
On complete intersections [PDF]
We construct closed complex submanifolds of dimension three in C^5 which are differential complete intersections but not holomorphic complete intersections.
Forstneric, Franc
core +2 more sources
KNIME-CDK: Workflow-driven cheminformatics [PDF]
Cheminformaticians have to routinely process and analyse libraries of small molecules. Among other things, that includes the standardization of molecules, calculation of various descriptors, visualisation of molecular structures, and downstream analysis.
Beisken, Stephan+5 more
openaire +3 more sources
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira+14 more
wiley +1 more source
Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional biochemical approaches and phosphoproteomics have provided valuable insights into CDK-mediated regulation,
Sachiya Nakashima+4 more
doaj +1 more source