Results 131 to 140 of about 69,053 (332)

Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1 [PDF]

, 2016
BACKGROUND: Modulation of protein activity by phosphorylation through kinases and subsequent de-phosphorylation by phosphatases is one of the most prominent cellular control mechanisms.
Dissmeyer, N., Hammann, P., Harashima, H., Kramer, K., Nakagami, H., Nomura, Y., Schnittger, A.   +6 more
core   +2 more sources

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

CDK1/2 toolbox in need of an upgrade [PDF]

Cell Cycle, 2016
Cyclin-dependent protein kinases are key drivers of cell cycle progression.1,2 Specific phases of the cycle are controlled by altering the levels and availability of cyclins which function to bind ...
Anisha Kothari, Timothy C. Chambers
openaire   +2 more sources

The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos. [PDF]

, 2015
Chromosome segregation during anaphase depends on chromosome-to-pole motility and pole-to-pole separation. We propose that in Drosophila embryos, the latter process (anaphase B) depends on a persistent kinesin-5-generated interpolar (ip) microtubule (MT)
Brust-Mascher, Ingrid, Scholey, Jonathan M, Wang, Haifeng   +2 more
core   +1 more source

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, EarlyView.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

Mitotic entry: The interplay between Cdk1, Plk1 and Bora [PDF]

Cell Cycle, 2016
Polo-like kinase 1 (Plk1) is an important mitotic kinase that is crucial for entry into mitosis after recovery from DNA damage-induced cell cycle arrest. Plk1 activation is promoted by the conserved protein Bora (SPAT-1 in C. elegans), which stimulates the phosphorylation of a conserved residue in the activation loop by the Aurora A kinase. In a recent
Parrilla, Alfonso, Cirillo, Luca, Thomas, Yann, Gotta, Monica, Pintard, Lionel, Santamaria, Anna   +5 more
openaire   +4 more sources

The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks

Cell Reports, 2016
Previous work has shown that Suc1/Cks proteins can promote the hyperphosphorylation of primed Cdk1 substrates through the formation of ternary Cdk1-Cks-phosphosubstrate complexes.
Sang Hoon Ha, Sun Young Kim, James E. Ferrell Jr.   +2 more
doaj   +1 more source

Cyclin-Dependent Kinase 1 Is Essential for Muscle Regeneration and Overload Muscle Fiber Hypertrophy

Frontiers in Cell and Developmental Biology, 2020
Satellite cell proliferation is an essential step in proper skeletal muscle development and muscle regeneration. However, the mechanisms regulating satellite cell proliferation are relatively unknown compared to the knowledge associated with the ...
Yutaka Kobayashi, Tomoyuki Tanaka, Mieradilli Mulati, Hiroki Ochi, Shingo Sato, Philipp Kaldis, Toshitaka Yoshii, Atsushi Okawa, Hiroyuki Inose   +8 more
doaj   +1 more source

Acanthamoeba induces cell-cycle arrest in host cells [PDF]

, 2004
Acanthamoeba can cause fatal granulomatous amoebic encephalitis (GAE) and eye keratitis. However, the pathogenesis and pathophysiology of these emerging diseases remain unclear.
Alizadeh, Alsam, Araki-Sasaki, Badenoch, Cao, Chynn, De Jonckheere, Di Gregorio, Dyson, Friedland, Gillett, Gonzalez, Gordon, Harbour, James Sissons, Jones, Khan, Khan, Khan, Khan, Khan, Kwang Sik Kim, Leher, Marciano-Cabral, Martinez, Mathers, Monique Stins, Moore, Morton, Naveed Ahmed Khan, Niederkorn, Pietenpol, Poggioli, Samantha Jayasekera, Selwa Alsam, Shin, Stevaux, van Klink, van Klink, Wright, Yang, Zhan   +41 more
core   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source