Results 141 to 150 of about 46,551 (257)

XDH Inhibits the Progression of Colorectal Cancer via Regulating Ferritinophagy Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
XDH inhibits the progression of CRC via mediating ferritinophagy and ferroptosis. Therefore, XDH/ferritinophagy may be a potential target for CRC. ABSTRACT Xanthine dehydrogenase (XDH) is involved in the progression of various cancer. This study aimed to investigate its potential in colorectal cancer (CRC). Gene expression was determined using RT‐qPCR,
Huiying Zhang, Meimei Yan, Mengya Li, Junjiao Gu, Xintao Wang, Jin Ding, Suxia Luo   +6 more
wiley   +1 more source

Preparation for mitosis requires gradual CDK1 activation

iScience
G2 phase is considered as a time in which cells prepare for the large structural changes in the following mitosis. Starting at completion of DNA replication, CDK1 and PLK1 kinase activities gradually increase throughout G2 phase until reaching levels that initiate mitosis.
Karen Akopyan, Zhiyu Hao, Arne Lindqvist
openaire   +4 more sources

Validation of the CDK1 hit from the LIM1215 siRNA screen in SW48 isogenic cell lines.

, 2016
(A) GTP-RAS assay showing the RAS activation status of SW48 KRAS isogenic cell lines. (B) KRAS dependence in the SW48 KRAS isogenic cell lines (*PKRAS mutant and the WT cell lines). (C) CDK1-specific siRNAs suppress CDK1 expression.
Sara Costa-Cabral (1808488), Alberto Bardelli (163979), Rachel Brough (96312), Jenna Riffell (1808491), Christopher Torrance (166866), Eliana Marinari (1808485), Christopher J. Lord (123616), James Campbell (81613), Marieke Aarts (22457), Alan Ashworth (1270), Asha Konde (1808494)   +10 more
core   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Cdk1-dependent phosphorylation of KIF4A at S1186 regulates the chromosomal localization of KIF4A during mitosis.

, 2018
(A) Localization of EGFP-KIF4A WT or S1186A was analyzed in fixed cells immunostained with anti-GFP (green) antibody. DNA was counterstained with Hoechst 33342 (blue). Arrowheads indicate chromosome bridge formation. Bar, 5 μm. EGFP-KIF4A WT localized to
Kiichi Fukui (2036467), Hideaki Takata (468699), Marliza Madung (6111434), Kaoru Katoh (6111437)   +3 more
core   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, Volume 46, Issue 6, Page 1735-1752, November 2026.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

CDK1 may promote breast cancer progression through AKT activation and immune modulation

Frontiers in Oncology
BackgroundCyclin-dependent kinase 1 (CDK1) plays a crucial role in regulating the cell cycle, yet its clinical relevance and molecular mechanisms in breast cancer remain insufficiently characterized.
Huanhong Zeng, Minxue Zhuang, Bochuan Liang, Feili Cai, Mengbo Lin, Ruijuan Wang, Ruo Wang, Hui Zhang   +7 more
doaj   +1 more source

Pharmacological and Therapeutic Potential of Garlic (Allium sativum): Integrating Phytochemistry, Molecular Mechanisms, and Clinical and Preclinical Evidence

ChemistryOpen, Volume 15, Issue 11, November 2026.
Garlic bioactive compounds, including organosulfur compounds (allicin, DADS, DATS, and SAC), phenolic compounds, and quercetin, regulate the Nrf2/HO‐1, NF‐κB, PI3K/Akt, and AMPK/eNOS signaling pathways. These actions enhance antioxidant defenses, suppress inflammation, improve metabolic and cardiovascular function, and contribute to reduced blood ...
Gudisa Bereda
wiley   +1 more source

Differential roles of cyclin-CDK1 complexes in cell migration and invasion [PDF]

We have previously described a central role for CDK1 at the nexus of adhesion signalling and cell cycle progression, demonstrating that CDK1 has a non-canonical role in regulating integrin adhesion complexes and in the migration of cancer cells in 3D ...
Jones, Michael J., Hartshorn, Matthew, Hetmanski, Joseph H.R., Jones, Matthew C., Caswell, Patrick T., Hetmanski, Joseph, Caswell, Patrick; id_orcid, Jones, Michael   +7 more
core   +1 more source

Evaluating Machine Learning Affinity Prediction Methods on Novel Lead Optimization Data: A 15‐PGDH Case Study

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Machine‐learning‐based protein–ligand affinity prediction has the potential to meaningfully impact drug discovery given their speed relative to traditional physics‐based methods. This case study considers recently disclosed inhibitors of 15‐hydroxyprostaglandin dehydrogenase and highlights the fragility of the domain of applicability of two methods ...
Alexander S. Rich, Leela S. Dodda, Daniel J. Price   +2 more
wiley   +1 more source