Results 161 to 170 of about 46,551 (257)
In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration
Advanced Science, Volume 13, Issue 60, 28 October 2026.Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 60, 28 October 2026.An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei +10 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 2001-2013, October 2026.Lung cancer cell lines diverge substantially from primary tumors at the transcriptional level. Using single‐sample gene set enrichment analysis and L1‐penalized feature selection across TCGA‐LUAD and CCLE‐LUAD, we identified five Hallmark pathways (E2F targets, G2M checkpoint, IFNγ response, coagulation, and EMT) that discriminated primary tumors from ...
Pritam Bera, Rajesh Raju, Debodipta Das
wiley +1 more source
CCNE1: A Cell Cycle Regulator That Influences Tumor Progression
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan +6 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 10, October 2026.Overview of the integrated computational framework used to investigate the Turmeric–Pueraria–Coix seed formula in rheumatoid arthritis. Phytochemical and disease‐associated targets were integrated with ferroptosis and oxidative‐stress genes, multicohort transcriptomics, machine learning, structural modeling, and single‐cell in silico perturbation to ...
Weiya Lan +9 more
wiley +1 more source
CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification
JCI InsightVascular calcification is a severe complication of cardiovascular diseases. Previous studies demonstrated that endothelial lineage cells transitioned into osteoblast-like cells and contributed to vascular calcification.
Yan Zhao +9 more
doaj +1 more source
Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia
iMeta, Volume 5, Issue 5, October 2026.Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen +23 more
wiley +1 more source
Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.ABSTRACT Circadian rhythms orchestrate a host of biological processes in a time‐dependent manner to maintain homeostasis in response to exercise. Within this framework, Rev‐erb‐α, an intracellular nuclear receptor and transcriptional regulator, transcends its role in circadian rhythms to drive myogenesis, muscle remodeling, primary metabolism, and ...
Ivo Vieira de Sousa Neto +7 more
wiley +1 more source