Results 181 to 190 of about 46,551 (257)

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

Cancer Science, Volume 117, Issue 10, Page 2769-2789, October 2026.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei, Yasutaka Yamada, Takaaki Tamura, Masahiro Sugiura, Xue Zhao, Meng Ni, Adilan Aierken, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto   +9 more
wiley   +1 more source

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, Volume 59, Issue 10, October 2026.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Driving Mitosis by Cdk1 and Greatwall

, 2015
promotiedatum: 26-3-2015 prom-id ...
openaire   +1 more source

DND1-NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3' UTRs. [PDF]

Mol Cell
Suzawa M, Qiu C, Polash AH, Yamaji M, Jacob AA, Horikawa W, Farroha EM, Barua M, Feng X, Liu C, Williams JG, Randazzo D, Sartorelli V, Valkov E, Yamaji M, Hall TMT, Hafner M.   +16 more
europepmc   +1 more source

Integrative Transcriptomic and Genetic Analyses Identify CDC20 as a Potential Biomarker Associated with Cell Cycle and Immune-Inflammatory Processes in Psoriasis. [PDF]

Clin Cosmet Investig Dermatol
Yang L, Mo W, Wang G, Wu X.
europepmc   +1 more source

Histone demethylase KDM4A promotes endometrial cancer progression through an ERRγ-associated cell-cycle regulatory axis. [PDF]

Int J Biol Sci
Chen J, Wen X, Zhang D, Zhu M, Zhou H, Li Y, Wan X.   +6 more
europepmc   +1 more source

HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis. [PDF]

Front Oncol
Li D, Cai Q, Lin L, Li L, Chen Y, Feng T, Zhou X, Xie J, Fu X, Li C, Xiao J, Yang F.   +11 more
europepmc   +1 more source

Molecular modeling of highly selective CDK1 Inhibitors based on pyrazolo-pyrimidines using 3D-QSAR, docking, and molecular dynamics simulations. [PDF]

PLoS One
Tahir MA, Chohan TA, Qayyum A, Yahya Abdullah Alzahrani A, R Alzahrani A, Ur Rehman Z, Khan A, Ashfaq K.   +7 more
europepmc   +1 more source

ROS scavenging mitigates TNFα-induced endoplasmic reticulum stress and mitochondrial fragmentation in human airway smooth muscle. [PDF]

Function (Oxf)
Dasgupta D, Mahadev Bhat S, Sieck GC.
europepmc   +1 more source

Exploring the mechanism of Shengmai San in treating lung adenocarcinoma based on bioinformatics and molecular dynamics simulation. [PDF]

Medicine (Baltimore)
Zhou X, Wu D, Zhang X, Zhang X.
europepmc   +1 more source