Results 191 to 200 of about 74,242 (343)

Unbiased Boolean analysis of public gene expression data for cell cycle gene identification. [PDF]

, 2019
Cell proliferation is essential for the development and maintenance of all organisms and is dysregulated in cancer. Using synchronized cells progressing through the cell cycle, pioneering microarray studies defined cell cycle genes based on cyclic ...
Dabydeen, Sarah A, Desai, Arshad, Sahoo, Debashis   +2 more
core   +1 more source

Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): Overexpression of NPM, CDK1 and NDRG1 and underexpression of CHES1 [PDF]

, 2005
Joseph Tung‐Chieh Chang, Hung‐Ming Wang, K.Y. Chang, Wen‐Ho Chen, Mingchun Wen, Yuan‐Ming Hsu, Benjamin Yat‐Ming Yung, I‐How Chen, Chun‐Ta Liao, Ling‐Ling Hsieh, Ann‐Joy Cheng   +10 more
openalex   +1 more source

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants

Glia, Volume 74, Issue 6, June 2026.
Zebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Darshini Ravishankar, Yuki Takeuchi, Ichiro Masai   +2 more
wiley   +1 more source

Cdk1: A kinase with changing substrate specificity [PDF]

Cell Cycle, 2011
Mardo, Kõivomägi, Mart, Loog
openaire   +2 more sources

Deubiquitinase YOD1 Inhibition Suppresses DEX‐ and Denervation‐Induced Muscle Atrophy Through MAFbx Destabilization

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains unclear. This study aims to identify a deubiquitinase (DUB)
Jongbeom Chae, Seon Min Woo, Seung Un Seo, Simmyung Yook, Hyo Je Cho, Jung Yeol Lee, Kyoung jin Min, Junhyeon Park, Dongryeol Ryu, Taeg Kyu Kwon   +9 more
wiley   +1 more source

CDK1 Inactivation Regulates Anaphase Spindle Dynamics and Cytokinesis In Vivo [PDF]

, 1997
Sally P. Wheatley, Edward H. Hinchcliffe, Michael Glotzer, Anthony A. Hyman, Greenfield Sluder, Yu-Li Wang   +5 more
openalex   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK [PDF]

, 2015
Nicholas R. Brown, S. Korolchuk, Mathew P. Martin, Will A. Stanley, R. Moukhametzianov, M.E.M. Noble, Jane Endicott   +6 more
openalex   +1 more source

TNMplot: An enhanced platform for pharmacological target identification through cross‐stage and pan‐cancer gene expression analysis

British Journal of Pharmacology, Volume 183, Issue 11, Page 2648-2659, June 2026.
TNMplot.com, a web‐based platform integrating RNA‐Seq and gene‐chip data from 56,938 samples, enables differential gene expression analysis across normal, primary tumour and metastatic tissues, facilitating large‐scale transcriptomic profiling across 22 tumour types.
Áron Bartha, Balázs Győrffy
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, Volume 16, Issue 5, Page 921-931, May 2026.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source