Results 171 to 180 of about 74,242 (343)

Diflubenzuron Caused Mitochondrial Dysfunction, Ca2+ Homeostasis Disruption, and Intrinsic Apoptosis in Trophoblastic Cells

Environmental Toxicology, EarlyView.
ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim, Wonhyoung Park, Whasun Lim, Gwonhwa Song, Sunwoo Park   +4 more
wiley   +1 more source

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Supplementary Figure 3 from Inhibition of Protein Phosphatase 2A Radiosensitizes Pancreatic Cancers by Modulating CDC25C/CDK1 and Homologous Recombination Repair [PDF]

, 2023
Dongping Wei, Leslie A. Parsels, David Karnak, Mary A. Davis, Joshua D. Parsels, Amanda C. Marsh, Lili Zhao, Jonathan Maybaum, Theodore S. Lawrence, Yi Sun, Meredith A. Morgan   +10 more
openalex   +1 more source

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

Molecules and Cells, 2019
Summary Since nuclear envelope breakdown occurs during mitosis in metazoan cells, it has been proposed that macroautophagy must be inhibited to maintain genome integrity.
Richard I. Odle, Simon A. Walker, David Oxley, Andrew M. Kidger, K. Balmanno, Rebecca Gilley, H. Okkenhaug, O. Florey, N. Ktistakis, S. Cook   +9 more
semanticscholar   +1 more source

A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis

Brain Pathology, EarlyView.
circRMST (hsa_circ_0099634) is by far the most abundant isoform from the RMST locus. It is highly expressed in cancer cells throughout ependymoma patient samples and is located in the cytoplasm. circRMST knockdown causes cell cycle arrest and induces differentiation, and it is a marker for poor prognosis. The figure is made using BioRender.
Ulvi Ahmadov, Charlotte W. Udengaard, Stine M. Vissing, Silke D. Nielsen, Kim‐Gwendolyn Dietrich, Benedicte Parm Ulhøi, Lasse S. Kristensen   +6 more
wiley   +1 more source

HAND2-AS1 plays a tumor-suppressive role in hepatoblastoma through the negative regulation of CDK1

Heliyon
Objective: Hepatoblastoma (HB) is the most commonly seen pediatric liver malignancy. The preliminary experiment of our research group found that cyclin dependent kinase 1 (CDK1) was upregulated in HB.
Keke Chen, Yalan You, Wenfang Tang, Xin Tian, Chengguang Zhu, Zexi Yin, Minhui Zeng, Xiangling He   +7 more
doaj   +1 more source

Tetrandrine enhances radiosensitivity through the CDC25C/CDK1/cyclin B1 pathway in nasopharyngeal carcinoma cells [PDF]

, 2017
Jun Wang, Lihong Chang, Xiaoping Lai, Xia Li, Zhiyuan Wang, Zizhen Huang, Jiancong Huang, Gehua Zhang   +7 more
openalex   +1 more source

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

Brain Pathology, EarlyView.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato, Satoru Miyawaki, Yu Sakai, Kenta Ohara, Yu Teranishi, Yudai Hirano, Motoyuki Umekawa, Takahiro Tsuchiya, Shotaro Ogawa, So Hirata, Hiroki Hongo, Hideaki Ono, Daisuke Komura, Tetsuo Ushiku, Shumpei Ishikawa, Nobuhito Saito   +15 more
wiley   +1 more source

CDK1 drives SOX9-mediated chemotherapeutic resistance in gastric cancer

Journal of Experimental & Clinical Cancer Research
Background Gastric carcinoma ranks as the fifth most common cause of cancer-related mortality globally. Chemoresistance remains a critical barrier to treatment efficacy, driving poor survival outcomes in gastric cancer patients. Cyclin-dependent kinase 1
Marwah Al-Mathkour, Zheng Chen, Julio Poveda, Longlong Cao, Oliver G. McDonald, Dunfa Peng, Mohammed Soutto, Zhibin Chen, Heng Lu, Yan Guo, Shria Kumar, Alexander Zaika, Silvia Giordano, Shoumin Zhu, Wael El-Rifai   +14 more
doaj   +1 more source

Chk1–cyclin A/Cdk1 axis regulates origin firing programs in mammals [PDF]

, 2009
Makoto Nakanishi, Yuko Katsuno, Hiroyuki Niida, Hiroshi Murakami, Midori Shimada   +4 more
openalex   +1 more source