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Cdk1 is sufficient to drive the mammalian cell cycle
Nature, 2007Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to drive cell division. In contrast, mammalian cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3, Cdk4 and Cdk6, to drive cells through interphase, as well as Cdk1 to proceed through mitosis.
David, Santamaría +9 more
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CDK1 is a marker of proliferation in human lymphoid cells
International Journal of Cancer, 1995AbstractTo better understand the relationship between the proliferation of human lymphoid cells and the expression of cdk1, a catalytic subunit of the histone HI kinase (HIK), we examined its mRNA and protein content in 3 B‐cell lines: Ramos, Reh‐6 and IARC 963. Cells were elutriated according to their position in the cell cycle.
D, Wołowiec +7 more
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2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors
Bioorganic & Medicinal Chemistry Letters, 2003Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties ...
Jirí, Moravec +9 more
openaire +2 more sources
2014
Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
openaire +2 more sources
Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
openaire +2 more sources
An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1)
Cancers, 2022Hao Wu, Zhenguo Liu, Xuanyou Liu
exaly
CDK1 promotes the stemness of lung cancer cells through interacting with Sox2
Clinical and Translational Oncology, 2021Zhen Huang
exaly
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis
Molecular Cell, 2021Stefano Maffini +2 more
exaly
MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer
Clinical and Translational Oncology, 2021Anquan Shang
exaly