Results 221 to 230 of about 46,551 (257)

Characterization of a novel cdk1‐related kinase

European Journal of Biochemistry, 1999
The p13suc1/p9CKShs proteins bind tightly to the cyclin‐dependent kinases cdk1 and cdk2. The distantly related protein, p15cdk‐BP, binds cdk4/6, cdk5 and cdk8. We now show that immobilized p15cdk‐BP binds both an HMG‐I kinase and a 35‐kDa protein that cross‐reacts with anti‐PSTAIRE antibodies (PSTAIRE is a totally conserved motif located in subdomain ...
L, Détivaud, G R, Pettit, L, Meijer
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Cep63 Recruits Cdk1 to the Centrosome—Letter

Cancer Research, 2015
In 2011, we published a characterization of the phenotypes of Cep63 downregulation and overexpression in human cells in Cancer Research ([1][1]). Recently, it was shown that several antibodies commonly used to detect Cdk1 cross-react with Cep152 ([2][2]).
Mohammad, Alsara, Harald, Löffler, Anne, Fechter, Jiri, Bartek, Alwin, Krämer   +4 more
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Cohesin and Cdk1: an anaphase barricade

Nature Cell Biology, 2010
Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
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Targets of the cyclin-dependent kinase Cdk1

Nature, 2003
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified.
Jeffrey A, Ubersax, Erika L, Woodbury, Phuong N, Quang, Maria, Paraz, Justin D, Blethrow, Kavita, Shah, Kevan M, Shokat, David O, Morgan   +7 more
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CDK1 in Breast Cancer: Implications for Theranostic Potential

Anti-Cancer Agents in Medicinal Chemistry, 2020
Breast cancer has been identified as one of the main cancer-related deaths among women during some last decades. Recent advances in the introduction of novel potent anti-cancer therapeutics in association with early detection methods led to a decrease in the mortality rate of breast cancer.
Sepideh Izadi, Afshin Nikkhoo, Mohammad Hojjat-Farsangi, Afshin Namdar, Gholamreza Azizi, Hamed Mohammadi, Mehdi Yousefi, Farhad Jadidi-Niaragh   +7 more
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Cdk1 and cell morphology: connections and directions

Current Opinion in Cell Biology, 2009
Cells undergo dramatic shape transitions as they progress through the cell cycle. Here, we discuss how communication between the ubiquitous cell cycle regulator Cdk1 and cell morphology factors such as Cdc42 coordinates the cell cycle and cell morphology in the budding and fission yeasts.
James B, Moseley, Paul, Nurse
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Cdk1: the dominant sibling of Cdk2

Nature Cell Biology, 2005
Cdk2 is thought to regulate entry into S phase, whereas Cdk1 controls the initiation of mitosis. New evidence shows that Cdk1 is equally capable of promoting the G1/S transition in Cdk2−/− cells, raising the question as to whether Cdk1 constitutes the predominant cyclin-dependent kinase in mammalian cells, or only compensates for Cdk2 function when it ...
Tarig Bashir, Michele Pagano
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[CDK1 expression and effects of CDK1 silencing on the malignant phenotype of glioma cells].

Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010
Our previous cDNA array data have shown that expression level of CDK1 increased along with the malignant progression of ganglioglioma, and decreased with the differentiation process of neural stem cells. The purpose of this study was to investigate the CDK1 expression levels in gliomas and the effects of CDK1 knockdown on phenotype of glioma cells ...
Hua, Chen, Qiang, Huang, De-zhong, Zhai, Jun, Dong, Ai-dong, Wang, Qing, Lan   +5 more
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Homology Model of the CDK1/cyclin B Complex

Journal of Biomolecular Structure and Dynamics, 2005
We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors. The preliminary model was formed from the homologous regions of the deposited CDK2/cyclin A crystal structure. Further refinement of the CDK1/cyclin B complex was accomplished using molecular
Connor F, McGrath, Nagarajan, Pattabiraman, Glen E, Kellogg, Thomas, Lemcke, Conrad, Kunick, Edward A, Sausville, Daniel W, Zaharevitz, Rick, Gussio   +7 more
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Phosphorylation by CDK1 regulates XMAP215 function in vitro

Cell Motility and the Cytoskeleton, 1999
XMAP215, a microtubule-associated protein isolated from Xenopus eggs, promotes microtubule assembly dynamics in an end-specific manner: addition of XMAP215 to purified porcine tubulin increases both elongation and shortening rates at microtubule plus ends, with minimal effects at minus ends.
R J, Vasquez, D L, Gard, L, Cassimeris
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