Results 301 to 310 of about 72,520 (322)

Integrative Multi-Omics Identifies CDK1 as a Key Signaling Regulator of CD4 ⁺ T Cell Effector Function

Servaas NH, Bauersachs HG, Abreu L, Claringbould A, Berest I, Schwarz JJ, Stein F, Fälth-Savitski M, Eismann L, Reddington JP, Zaugg JB.   +10 more
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Correlation between CDK1 protein and CDK1 mRNA during oocyte maturation in mouse

The International Journal of Developmental Biology, 2022
The aim of this study was to investigate the correlation between CDK1 protein and CDK1 mRNA during oocyte maturation in vivo in mouse. GV, GVBD, MI and MII oocytes were obtained from mice, respectively. Western blot validated that the CDK1 protein expression increased continuously and significantly with oocyte maturation in vivo (P<0.05).
Ya-Ting, Sun, Ai-Zhen, Zhu
openaire   +2 more sources

CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer

Gut, 2020
Objective Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy.
Jin Huang, Pan Chen, Ke-Wei Liu, Jiao Liu, Borong Zhou, Runliu Wu, Qiu Peng, Ze-xian Liu, Changfeng Li, G. Kroemer, M. Lotze, H. Zeh, R. Kang, D. Tang   +13 more
semanticscholar   +1 more source

CDK1 in Breast Cancer: Implications for Theranostic Potential.

Anti-Cancer Agents in Medicinal Chemistry, 2020
Breast cancer has been identified as one of the main cancer-related deaths among women during some last decades. Recent advances in the introduction of novel potent anti-cancer therapeutics in association with early detection methods led to a decrease in
Sepideh Izadi, A. Nikkhoo, M. Hojjat-Farsangi, A. Namdar, G. Azizi, H. Mohammadi, M. Yousefi, F. Jadidi‐Niaragh   +7 more
semanticscholar   +1 more source

Targets of the cyclin-dependent kinase Cdk1

Nature, 2003
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified.
Jeffrey A, Ubersax, Erika L, Woodbury, Phuong N, Quang, Maria, Paraz, Justin D, Blethrow, Kavita, Shah, Kevan M, Shokat, David O, Morgan   +7 more
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Cohesin and Cdk1: an anaphase barricade

Nature Cell Biology, 2010
Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
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Cdk1 and cell morphology: connections and directions

Current Opinion in Cell Biology, 2009
Cells undergo dramatic shape transitions as they progress through the cell cycle. Here, we discuss how communication between the ubiquitous cell cycle regulator Cdk1 and cell morphology factors such as Cdc42 coordinates the cell cycle and cell morphology in the budding and fission yeasts.
James B, Moseley, Paul, Nurse
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2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors

Bioorganic & Medicinal Chemistry Letters, 2003
Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties ...
Jirí, Moravec, Vladimír, Krystof, Jan, Hanus, Libor, Havlícek, Daniela, Moravcová, Kvetoslava, Fuksová, Marek, Kuzma, René, Lenobel, Michal, Otyepka, Miroslav, Strnad   +9 more
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Cdk1 Regulates Anaphase Onset

2014
Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
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Cep63 Recruits Cdk1 to the Centrosome—Letter

Cancer Research, 2015
In 2011, we published a characterization of the phenotypes of Cep63 downregulation and overexpression in human cells in Cancer Research ([1][1]). Recently, it was shown that several antibodies commonly used to detect Cdk1 cross-react with Cep152 ([2][2]).
Mohammad, Alsara, Harald, Löffler, Anne, Fechter, Jiri, Bartek, Alwin, Krämer   +4 more
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