Results 321 to 329 of about 67,859 (329)
Cdk1: conductor of CENP-A symphony orchestra [PDF]
Science Bulletin, 2015 The inheritance of human genome through mitosis is precisely regulated by a series of tightly orchestrated events such as chromosome condensation, bi-orientated spindle formation, chromosome congression, segregation and cytokinesis. Chromosome movements during mitosis are governed by dynamic interactions of spindle microtubules with a specialized ...
Xuebiao Yao, Changjiang Jin
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CDK1 in Breast Cancer: Implications for Theranostic Potential.
Anti-Cancer Agents in Medicinal Chemistry, 2020Breast cancer has been identified as one of the main cancer-related deaths among women during some last decades. Recent advances in the introduction of novel potent anti-cancer therapeutics in association with early detection methods led to a decrease in
Sepideh Izadi +7 more
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Phosphorylation by CDK1 regulates XMAP215 function in vitro
Cell Motility and the Cytoskeleton, 1999XMAP215, a microtubule-associated protein isolated from Xenopus eggs, promotes microtubule assembly dynamics in an end-specific manner: addition of XMAP215 to purified porcine tubulin increases both elongation and shortening rates at microtubule plus ends, with minimal effects at minus ends.
Lynne Cassimeris +2 more
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Cdk1 Is Essential for Mammalian Cyclosome/APC Regulation
Experimental Cell Research, 2000The cyclosome/APC (anaphase-promoting complex), the major component of cell-cycle-specific ubiquitin-mediated proteolysis of mitotic cyclins and of other cell cycle proteins, is essential for sister chromatid separation and for exit from mitosis. Cyclosome activity and substrate specificity are modulated by phosphorylation and by transient interactions
Amit Zor +3 more
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2014
Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
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Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
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Cdk1 is sufficient to drive the mammalian cell cycle
Nature, 2007Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to drive cell division. In contrast, mammalian cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3, Cdk4 and Cdk6, to drive cells through interphase, as well as Cdk1 to proceed through mitosis.
Javier F. Cáceres +10 more
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CDK1 promotes the stemness of lung cancer cells through interacting with Sox2
Clinical and Translational Oncology, 2021Z. Huang, G. Shen, J. Gao
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MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer
Clinical and Translational Oncology, 2021J. Tang +6 more
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