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A Cdk5 inhibitor restores cognitive function and alleviates type 2 diabetes in mice. [PDF]

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A decade of CDK5

Nature Reviews Molecular Cell Biology, 2001
Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug ...
R, Dhavan, L H, Tsai
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