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CDK5–cyclin B1 regulates mitotic fidelity
NatureCDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392 ...
Xiao-Feng Zheng +15 more
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Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 2001
Mammalian brains are highly compartmentalized into groups of functionally specialized neurons. Cell migration and neurite outgrowth must be tightly orchestrated to achieve this level of organization. A small serine/threonine kinase that shows homology to cyclin-dependent kinases (Cdks) has emerged as an important regulator of neuronal migration.
D S, Smith, P L, Greer, L H, Tsai
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Mammalian brains are highly compartmentalized into groups of functionally specialized neurons. Cell migration and neurite outgrowth must be tightly orchestrated to achieve this level of organization. A small serine/threonine kinase that shows homology to cyclin-dependent kinases (Cdks) has emerged as an important regulator of neuronal migration.
D S, Smith, P L, Greer, L H, Tsai
openaire +1 more source
[CDK5 and neurodegenerative disease].
Sheng li ke xue jin zhan [Progress in physiology], 2004Ying-Peng, Wang +2 more
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