Results 61 to 70 of about 28,778 (201)

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis [PDF]

, 2015
Background Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the possibility that CDK5 modulation could ...
A Arif, AK Fu, AK Upadhyay, AR Cole, AR Cole, B Tian, BS Li, C Huang, C Vuaillat, C. James Hastie, Calum Sutherland, CJ Strock, D Tang, D Tang, DJ Giard, DO Morgan, Douglas J. Lamont, DP Hanger, E Contreras-Vallejos, E Oliemuller, E Petsalaki, EC Gilmore, EE Vincent, EF Schmidt, F Causeret, F Plattner, Francis A. Carey, G Feldmann, G Kusakawa, GN Patrick, HS Choi, J Ko, J Lindqvist, J Yuasa-Kawada, J Zhang, JA Bibb, JP Eggers, JY Shih, JY Shih, K Pozo, K Pozo, K Shimada, KY Lee, L Cao, LH Tsai, M Brown, MS Lee, Nicholas A. Morrice, Nicola J. Grant, P Vincent, Philip J. Coates, RY Poon, S Patel, SM Ehrlich, SP Banks-Schlegel, Susan E. Bray, T Chae, T Kimura, T Ohshima, T Ohshima, T Sandal, WQ Fang, WY Fu, X Gao, X Liu, Y Watanabe, YT Kwon, YT Kwon, Yvonne L. Woods, Z Songyang, ZH Cheung   +70 more
core   +3 more sources

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

CDK5 downregulation enhances synaptic plasticity

Cellular and Molecular Life Sciences, 2016
CDK5 is a serine/threonine kinase that is involved in the normal function of the adult brain and plays a role in neurotransmission and synaptic plasticity. However, its over-regulation has been associated with Tau hyperphosphorylation and cognitive deficits.
Rafael Andrés Posada-Duque, Omar Ramirez, Steffen Härtel, Nibaldo C. Inestrosa, Felipe Bodaleo, Christian González-Billault, Alfredo Kirkwood, Gloria Patricia Cardona-Gómez   +7 more
openaire   +7 more sources

Long and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer´s mice

Frontiers in Aging Neuroscience, 2014
CDK5 is a member of the cyclin-dependent kinase family with diverse functions in both the developing and mature nervous system. The inappropriate activation of CDK5 due to the proteolytic release of the activator fragment p25 from the membrane ...
John Fredy Castro-Alvarez, Sergio Alejandro Uribe-Arias, Kenneth S Kosik, Gloria Patricia eCardona-Gomez   +3 more
doaj   +1 more source

Post‐Translational Modifications in Animal Circadian Clocks

Advanced Science, EarlyView.
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley   +1 more source

Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening

Journal of Biomedical Science, 2009
Background Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is the lack of reproducible and well ...
Hiller Gösta, Malmström Jonas, Ottervald Jan, Radesäter Ann-Cathrin, Agerman Karin, Jämsä Anne, Liu Gang, Vasänge Mervi   +7 more
doaj   +1 more source

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration [PDF]

, 2018
Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and ανβ3 integrin.
A Bogush, A Hernandez, A Polykratis, AH Hawasli, C González-Castillo, C Heiss, C Marinaccio, C Mikelis, DH Ausprunk, E Contreras-Vallejos, E Lampropoulou, E Papadimitriou, E Papadimitriou, E Szabat, E Řezníčková, G Herradón, H Merk, H Pariser, H Yanagisawa, HJ Yeh, J Herzog, J Liebl, J Liebl, J Liebl, J Yao, JK Jin, K Meng, K Shah, K Shah, KO Lai, KP Sarker, L He, LJ Zhang, M Koutsioumpa, M Koutsioumpa, M Koutsioumpa, M Nikolic, MA Fousteris, MH Lee, MJ Xavier, MM Mandl, MR Hellmich, MR Sharma, N Franceschi De, N Mitsios, N Olmo del, ND Amin, S Tsirmoula, S Zhang, SB Weitensteiner, SS Sun, T Skillbäck, V Lalioti, Y Gao   +53 more
core   +2 more sources

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Cdk5 Phosphorylates a Component of the HDAC Complex and Regulates Histone Acetylation during Neuronal Cell Death

Neurosignals, 2012
Cyclin-dependent kinase 5 (Cdk5), a member of the cyclin-dependent kinase family, is critical for regulating neural development and neuronal survival.
Amy K.Y. Fu, Kwok-Wang Hung, Hovy Ho-Wai Wong, Wing-Yu Fu, Nancy Y. Ip   +4 more
doaj   +1 more source

Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice. [PDF]

PLoS ONE, 2014
Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous system.
Erick Contreras-Vallejos, Elías Utreras, Daniel A Bórquez, Michaela Prochazkova, Anita Terse, Howard Jaffe, Andrea Toledo, Cristina Arruti, Harish C Pant, Ashok B Kulkarni, Christian González-Billault   +10 more
doaj   +1 more source