Results 61 to 70 of about 14,231 (159)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica +16 more
wiley +1 more source
Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, Volume 13, Issue 14, 9 March 2026.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source
Cdk5 inhibitory peptide (CIP) inhibits Cdk5/p25 activity induced by high glucose in pancreatic beta cells and recovers insulin secretion from p25 damage. [PDF]
PLoS ONE, 2013 Cdk5/p25 hyperactivity has been demonstrated to lead to neuron apoptosis and degenerations. Chronic exposure to high glucose (HG) results in hyperactivity of Cdk5 and reduced insulin secretion.
Ya-Li Zheng +11 more
doaj +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen +12 more
wiley +1 more source
Neuroprotective Mechanisms Mediated by CDK5 Inhibition [PDF]
Current Pharmaceutical Design, 2016 Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase belonging to the family of cyclin-dependent kinases. In addition to maintaining the neuronal architecture, CDK5 plays an important role in the regulation of synaptic plasticity, neurotransmitter release, neuron migration and neurite outgrowth.
Gohar, Mushtaq +6 more
openaire +2 more sources
Post‐Translational Modifications in Animal Circadian Clocks
Advanced Science, Volume 13, Issue 16, 18 March 2026.Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley +1 more source
eLife, 2017 Cdk5 is a post-mitotic kinase with complex roles in maintaining neuronal health. The various mechanisms by which Cdk5 inhibits and promotes neurodegeneration are still poorly understood.
Nilay Nandi +3 more
doaj +1 more source
The Genetic Basis of Color Polymorphism in the Orb‐Web Spider Gasteracantha cancriformis
Ecology and Evolution, Volume 16, Issue 3, March 2026.This study investigates the genetic basis of coloration in the polymorphic spider Gasteracantha cancriformis using RNA‐seq data from different female color morphs. We assembled a reference transcriptome and identified differentially expressed genes associated with known pigmentation pathways, including carotenoids, melanin, ommochromes, and pteridines.
Paula Torres‐Quintero +3 more
wiley +1 more source
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.
PLoS Biology, 2007 Neurotrophins are key regulators of neuronal survival and differentiation during development. Activation of their cognate receptors, Trk receptors, a family of receptor tyrosine kinases (RTKs), is pivotal for mediating the downstream functions of ...
Zelda H Cheung +4 more
doaj +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.This strategy employs micro‐arc oxidation to construct a composite coating containing nano‐hydroxyapatite (nHA) and chloride ions (Cl−), enabling dual regulation of the implant interface microenvironment during the critical postoperative stage. The released Ca²⁺ and PO₄³− from nHA activate osteogenic signaling pathways, enhancing osteoblast adhesion ...
Zhiqiang Qi +10 more
wiley +1 more source