Results 81 to 90 of about 28,778 (201)

Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus [PDF]

, 2011
Increased levels of glutamate causing excitotoxic damage accompany neurological disorders such as ischemia/stroke, epilepsy and some neurodegenerative diseases.
Belluardo, N., Korhonen, L., Kukkonen, J., Lindholm, D., Mudo', G., Putkonen, N., Putula, J.   +6 more
core   +1 more source

Role of Septin7 in mitochondrial dynamics and oxidative metabolism in C2C12 skeletal muscle cells

The Journal of Physiology, EarlyView.
Abstract figure legend Knockdown of Septin7 alters the expression of markers responsible for mitochondrial dynamics. Members of the electron transport chain are also affected by diminished Septin7 level resulting in functional changes of mitochondrial respiration. Abstract Mitochondria are dynamic organelles that undergo fusion and fission.
Andrea Telek, Ivett Gabriella Szabó, Anikó Keller‐Pintér, Mónika Gönczi, Eliza Guti, László Szabó, Brigitta Tillmann, Zoltán Márton Kohler, László Juhász, Péter Bai, Szilárd Póliska, Zsuzsanna Gaál, László Csernoch, János Fodor   +13 more
wiley   +1 more source

Cdk5 interacts with Hif-1α in neurons: A new hypoxic signalling mechanism? [PDF]

, 2011
The cyclin dependent kinase 5 (Cdk5)/p35 complex is essential for regulation of cell survival during development and in models of neuronal excitotoxicity.
Antoniou, Bouvry, Brahimi-Horn, Cheung, Escuin, Fandrey, Friedman, Genc, Gorlach, Hayashi, Hirota, Hopfl, Jin, Koh, Lau, Li, Liu, Ma, Max Gassmann, Mitsios, Nguyen, Nikolic, O'Hare, Ogunshola, Omolara O. Ogunshola, Patrick, Qu, Saito, Sharma, Shelton, Slevin, Strocchi, Wang, Xanthi Antoniou   +33 more
core   +1 more source

Computational Algorithmic Innovations in Differential Equation‐Based Dynamic Process Modeling

Engineering Reports, Volume 8, Issue 2, February 2026.
This study presents algorithmic innovations in Neural Ordinary Differential Equations (NeuralODEs) for dynamic process modeling of complex biochemical systems. Using the DARPP‐32 signaling network as a benchmark, the proposed framework demonstrates accurate replication of ODE and Rule‐Based Model behaviors while offering enhanced modularity ...
Guobin Zeng
wiley   +1 more source

A hippocampal Cdk5 pathway regulates extinction of contextual fear [PDF]

, 2007
Treatment of emotional disorders involves the promotion of extinction processes, which are defined as the learned reduction of fear. The molecular mechanisms underlying extinction have only begun to be elucidated. By employing genetic and pharmacological
A Burgos-Robles, A Fischer, A Fischer, A Fischer, A Fischer, A Fischer, A Matus, Ammar H Hawasli, Andre Fischer, AR Delamater, AY Nakayama, BS Li, CH Lin, Christina Schrick, DC Edwards, DC Howell, DE Berman, DJ Berlau, F Sotres-Bayon, Farahnaz Sananbenesi, G Marsicano, G Szapiro, H Wang, Jelena Radulovic, JJ Kim, JP Chhatwal, K Tomizawa, KM Lattal, KM Myers, KM Myers, L Desire, Li-Huei Tsai, M Angelo, M Davis, M Kitagawa, M Lei, M Nikolic, M Nikolic, ML Hayashi, MR Vianna, QG Zhang, R Dhavan, Rachael Neve, S Arber, ST Wong, SY Lee, T Bonhoeffer, T Ohshima, T Rashid, TC Tan, WA Falls, WY Fu, Xinyu Wang, Y Fukazawa, Y Kim, ZH Cheung   +55 more
core   +1 more source

Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth‐Associated Proteins

Aging Cell, Volume 25, Issue 2, February 2026.
We characterized the plasma proteomic profiles of centenarians from the SWISS100 cohort, identifying 583 differentially expressed proteins compared to younger and geriatric groups. Cross‐validation with the independent datasets NECS and the TAME consortium confirmed a robust aging signature, while fractional polynomial regressions revealed a specific ...
Flavien Delhaes, Justine Falciola, Adar Hoffman, Stéphanie Carnesecchi, Stefano Cavalli, Armin von Gunten, Daniela S. Jopp, François R. Herrmann, Karl‐Heinz Krause   +8 more
wiley   +1 more source

Neuroprotective Mechanisms Mediated by CDK5 Inhibition [PDF]

Current Pharmaceutical Design, 2016
Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase belonging to the family of cyclin-dependent kinases. In addition to maintaining the neuronal architecture, CDK5 plays an important role in the regulation of synaptic plasticity, neurotransmitter release, neuron migration and neurite outgrowth.
Gohar, Mushtaq, Nigel H, Greig, Firoz, Anwar, Fahad A, Al-Abbasi, Mazin A, Zamzami, Hasan A, Al-Talhi, Mohammad A, Kamal   +6 more
openaire   +2 more sources

The Role of Cdk5 in neuronal death and synaptic dysfunctions through phosphorylating FOXO1 and BAG3 [PDF]

, 2016
细胞周期蛋白依赖性激酶5（Cyclin-dependentkinase5，Cdk5）是由脯氨酸介导的丝氨酸/苏氨酸蛋白激酶，其在神经系统中发挥着重要的作用。Cdk5的活化主要靠神经系统中广泛表达的两个激活因子p35和p39。Cdk5对神经系统的正常生理功能具有重要作用去，其可通过磷酸化众多底物的丝氨酸/苏氨酸位点，在神经元的迁移分化，突触传递，轴突树突的发育过程以及神经元的存活中都发挥着重要的作用。此外，在某些病理条件下，Calpain所介导的p35切割形成p25，可以过度激活Cdk5 ...
周杰超
core  

Leveraging 3D Molecular Spatial Visual Information and Multi‐Perspective Representations for Drug Discovery

Advanced Science, Volume 13, Issue 2, 9 January 2026.
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang, Xi Zhou, Yujie Qi, Xiaobo Zhu, Xun Deng, Feng Tan, Yuan Huang, Lun Hu, Zhuhong You, Pengwei Hu   +9 more
wiley   +1 more source

Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.

PLoS Biology, 2007
Neurotrophins are key regulators of neuronal survival and differentiation during development. Activation of their cognate receptors, Trk receptors, a family of receptor tyrosine kinases (RTKs), is pivotal for mediating the downstream functions of ...
Zelda H Cheung, Wing Hong Chin, Yu Chen, Yu Pong Ng, Nancy Y Ip   +4 more
doaj   +1 more source