Results 81 to 90 of about 14,231 (159)

Regulation of Microtubule Stability in Pulmonary Microvascular Endothelial Cells in Rats with Severe Acute Pancreatitis: Qingyi Decoction is a Potential CDK5 Inhibitor

Journal of Inflammation Research
Yinan Cao,1– 3,* Fan Li,1– 3,* Zhenxuan Sun,1– 3 Jin Liu,1– 3 Jie Liu,1– 3 Qi Yang,1– 3 Peng Ge,1– 3 Yalan Luo,1– 3 Hailong Chen1– 3 1Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning ...
Cao Y, Li F, Sun Z, Liu J, Liu J, Yang Q, Ge P, Luo Y, Chen H   +8 more
doaj  

Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders

Molecular Neurodegeneration, 2011
Background Recent studies suggest that the pathogenic process in neurodegenerative disorders may disrupt mature neuronal circuitries and neurogenesis in the adult brain.
Rockenstein Edward, Achim Cristian L, Trejo-Morales Margarita, Dumaop Wilmar, Patrick Christina, Ruf Rebecca, Crews Leslie, Masliah Eliezer   +7 more
doaj   +1 more source

Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons.

PLoS ONE, 2012
We investigated possible involvement of a calpain/p35-p25/cyclin-dependent kinase 5 (Cdk5) signaling pathway in modifying NMDA receptors (NMDARs) in glutamate-induced injury of cultured rat retinal neurons.
Yanying Miao, Ling-Dan Dong, Jie Chen, Xiao-Chen Hu, Xiong-Li Yang, Zhongfeng Wang   +5 more
doaj   +1 more source

CDK5: A new lead to survival [PDF]

Cell Cycle, 2013
The protein kinase CDK5 was originally discovered at a time when cyclin-dependent kinases were thought to be involved exclusively in cell cycle control. The CDK5 catalytic subunit was first identified based on its nucleotide sequence homology to other known CDK family members (cdc2, CDK2),1 while the enzyme activity was identified by protein ...
openaire   +2 more sources

Activation of Cyclin-Dependent Kinase 5 Mediates Orofacial Mechanical Hyperalgesia

Molecular Pain, 2013
Background Cyclin-dependent kinase 5 (Cdk5) is a unique member of the serine/threonine kinase family. This kinase plays an important role in neuronal development, and deregulation of its activity leads to neurodegenerative disorders.
Michaela Prochazkova, Anita Terse, Niranjana D Amin, Bradford Hall, Elias Utreras, Harish C Pant, Ashok B Kulkami   +6 more
doaj   +1 more source

Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic Mice

Neurobiology of Disease, 2001
The potential contribution of cyclin-dependent protein kinase 5 (cdk5) to hyperphosphorylate protein tau, as claimed in Alzheimer's disease, was investigated in vivo.
C. Van den Haute, K. Spittaels, J. Van Dorpe, R. Lasrado, K. Vandezande, I. Laenen, H. Geerts, F. Van Leuven   +7 more
doaj   +1 more source

Prenatal p25-activated Cdk5 induces pituitary tumorigenesis through MCM2 phosphorylation-mediated cell proliferation

Neoplasia: An International Journal for Oncology Research
Aberrant expression of cyclin-dependent kinase 5 (Cdk5) has been reported in pituitary adenomas. However, the role of Cdk5 in the tumorigenesis remains unclear. We show that prenatal p25-activated Cdk5 phosphorylates minichromosome maintenance protein 2 (
Yingwei Huang, Qiqi Wang, Weiwei Zhou, Yawei Jiang, Kai He, Wei Huang, Yating Feng, Hong Wu, Lijuan Liu, Yue Pan, Yihua Huang, Zirui Chen, Wei Li, Yaowei Huang, Guanchuan Lin, Yulong Zhang, Yongyan Ren, Kaibiao Xu, Yanlin Yu, Yuping Peng, Xinghua Pan, Suyue Pan, Hailiang Hu, Yafang Hu   +23 more
doaj   +1 more source

Cdk5

, 2017
FONDECYT
openaire   +1 more source

CDK5 Gene [PDF]

, 2020
openaire   +1 more source

Cdk5: Links to DNA damage [PDF]

Cell Cycle, 2010
En, Huang, Dianbo, Qu, David S, Park
openaire   +2 more sources