Results 101 to 110 of about 61,476 (246)
iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source
LncRNA-ANRIL regulates CDKN2A to promote malignant proliferation of Kasumi-1 cells
Cell DivisionObjective This study aimed to investigate the regulatory effects of long non-coding RNA-ANRIL on CDKN2A in the cell cycle of Kasumi-1 cells and elucidate the underlying molecular mechanisms.
Jianxia Xu +10 more
doaj +1 more source
Acta Dermato-Venereologica, 2018 Approximately 5–10% of melanoma cases occur in a familial context. CDKN2A/CDK4 were the first high-penetrance melanoma genes identified. The aims of this study were to evaluate CDKN2A/CDK4 variants in Greek familial melanoma patients and to correlate the
Fani Karagianni +15 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.Liquid biopsy uses non‐invasive sampling of blood or body fluids to isolate circulating analytes, including circulating tumor DNA, circulating tumor cells, extracellular vesicles, and RNA. These are analyzed using next‐generation sequencing, qPCR, and proteomics to inform cancer detection, monitoring, and characterization. Figure created with BioRender.
Jaswinder Singh +2 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin +4 more
wiley +1 more source
Hazard ratios for CM in CDKN2A carriers according to MC1R genotype, compared to all CDKN2A carriers.
, 2015 Using Cox regressionHazard ratios for CM in CDKN2A carriers according to MC1R genotype, compared to all CDKN2A carriers.
Åke Borg (1280) +19 more
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol +4 more
wiley +1 more source
Reflectance Confocal Microscopy Features of Nevoid Melanoma: Case Report and Literature Review
JEADV Clinical Practice, EarlyView.ABSTRACT Nevoid melanoma (NM) is a rare melanoma variant that often mimics benign compound or intradermal nevi, both clinically and histopathologically. Due to its deceptively benign appearance, diagnosis is frequently delayed, resulting in advanced Breslow thickness at presentation.
Umberto Santaniello +6 more
wiley +1 more source
Previous studiesindicatearoleof CDKN2A/2B/2BAS genes inatherosclerosisand type 2diabetesmellitus(T2DM).Progressionofthesediseasesisaccompaniedby T-cell imbalanceandchronicinflammation.Ourmainobjectivewastoinvestigate a potentialassociationbetween CDKN2A ...
Sanz Ferrando, María Jesús +9 more
core +1 more source
, 2014 Melanoma is a highly aggressive cancer, accounting for up to 75% of skin cancer deaths. A small proportion of melanoma cases can be ascribed to the presence of highly penetrant germline mutations, and approximately 40% of hereditary melanoma cases are ...
Duprat, João Pereira +12 more
core +1 more source