Results 81 to 90 of about 61,476 (246)

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

MiR-484 promotes the malignant progression of glioma by inhibiting CDKN2A expression

Folia Neuropathologica, 2023
Yingrui Gu, Hongbing Lei, Peipei Ma, Yi Chen   +3 more
doaj   +1 more source

Homozygous CDKN2A/B deletions in low- and high-grade glioma: a meta-analysis of individual patient data and predictive values of p16 immunohistochemistry testing

Acta Neuropathologica Communications
CDKN2A/B deletions are prognostically relevant in low- and high-grade gliomas. Data on this is derived from heterogeneous series, an accurate estimation of survival risk from homozygous CDKN2A/B deletion is missing.
Darius Noack, Johannes Wach, Alonso Barrantes-Freer, Nils H. Nicolay, Erdem Güresir, Clemens Seidel   +5 more
doaj   +1 more source

Genetic study of the CDKN2A and CDKN2B genes in renal cell carcinoma patients

Practical Laboratory Medicine
Objectives: While recent studies have demonstrated several genetic alterations are associated with pathogenesis of RCC, the significance of cyclin-dependent kinase inhibitor 2A (CDKN2A) and cyclin-dependent kinase inhibitor 2B (CDKN2B) in tumorigenesis ...
Nattaradee Kiatprungvech, Premsant Sangkum, Rozita Malinee, Suchada Sommaluan, Veerawat Korkiatsakul, Suchin Worawichawong, Budsaba Rerkamnuaychoke, Adcharee Kongruang, Suraida Aeesoa, Panuwat Lertsithichai, Kittinut Kijvikai, Wisoot Kongchareonsombat, Teerapong Siriboonpiputtana   +12 more
doaj   +1 more source

CDKN2A pyrosequencing.

, 2013
10 CpG sites analyzed in the CpG Island of the CDKN2A gene. The y axis represents the signal intensity, while the x axis shows the dispensation order. The blue color indicate the % of methylation at each CpG site.
Francesca Migheli (289246), John C. Mathers (118472), Fabio Coppedè (289252), Alessandra Failli (289255), Rita Consolini (289257), Massimo Seccia (29407), Wan Adnan Wan Omar (289254), Paolo Miccoli (289262), Andrea Stoccoro (289248), Roberto Spisni (289260), Lucia Migliore (289264)   +10 more
core   +1 more source

Elevated CDKN2A expression distinguishes basal-like human breast cancer.

, 2022
Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4).
Shahan Mamoor
core   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2018
BackgroundHPV infection is associated with high p16 expression and good prognosis in head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene encoding p16, may further elucidate the association between p16 expression and prognosis ...
William S. Chen, Ranjit S. Bindra, Ranjit S. Bindra, Allen Mo, Thomas Hayman, Zain Husain, Zain Husain, Joseph N. Contessa, Joseph N. Contessa, Stephen G. Gaffney, Jeffrey P. Townsend, James B. Yu, James B. Yu, James B. Yu   +13 more
doaj   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Genomic rearrangements of the CDKN2A locus are infrequent in Italian malignant melanoma families without evidence of CDKN2A/CDK4 point mutations

, 2008
Predisposition to familial cutaneous malignant melanoma has been associated with mutations in the CDKN2A and CDK4 genes. However, only a small subgroup of melanoma pedigrees harbour CDKN2A or CDK4 germline mutations.
GHIORZO P, GHIORZO, PAOLA, SESTINI R, BRUNO W, MANOUKIAN S, ORLANDO C, BRUNO, WILLIAM, SCAINI, MARIACHIARA, SCAINI MC, D'ANDREA E, TESTORI A, MENIN C, BIANCHI SCARRA G, PIAZZINI M, GENSINI F, VIGNOLI M, BIANCHI, GIOVANNA, GENUARDI M., D'ANDREA, EMMA, Genuardi, M   +19 more
core   +2 more sources