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The global dynamics of CDK substrate phosphorylation in a simplified CDK network
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Recent advances on cyclins, CDKs and CDK inhibitors
Trends in Cell Biology, 1997In eukaryotes, cell division is controlled by cyclin-dependent kinases (CDKs). Here we summarize a few new developments on the regulation of the cell cycle by CDK-cyclin complexes. We have focused on three aspects in which there has been recent progress: the structural analysis of these complexes, the phenotypes of mice carrying knockouts of CDK ...
Cristina MartÃn-Castellanos
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Seminars in Cancer Biology, 1995
The connections between cancer and the basic machinery of the cell cycle have taken a surprisingly long time to become apparent. However, the past 2 years has seen a dramatic increase in the number of cell cycles regulators that have been implicated as either protooncogenes or as tumour suppressor genes.
Jonathon Pines
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The connections between cancer and the basic machinery of the cell cycle have taken a surprisingly long time to become apparent. However, the past 2 years has seen a dramatic increase in the number of cell cycles regulators that have been implicated as either protooncogenes or as tumour suppressor genes.
Jonathon Pines
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Cell, 2005 SummaryCyclin-dependent kinases (CDKs) restrict DNA replication origin firing to once per cell cycle by preventing the assembly of prereplicative complexes (pre-RCs; licensing) outside of G1 phase. Paradoxically, under certain circumstances, CDKs such as
Niels Mailand, John F X Diffley
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Regulation of CDKs by phosphorylation
1998The key transitions of the cell cycle are controlled via the sequential activation and inactivation of members of the cyclin-dependent kinase (CDK) subfamily of protein kinases. The activities of these enzymes are regulated by multiple mechanisms including both activating and inactivating phosphorylations, binding to regulatory subunits termed cyclins,
M J, Solomon, P, Kaldis
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Nature, 1995
As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.
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As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.
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Cdk inhibitors in development and cancer
Current Opinion in Genetics & Development, 1996Activation of cyclin-dependent kinases is the primary control point of cell proliferation. Recent advances in the understanding of cell-cycle regulation have uncovered two families of proteins that bind and inhibit these kinases. These proteins are likely mediators of development and differentiation, and may provide molecular connections between the ...
J W, Harper, S J, Elledge
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The INK4 Family of CDK Inhibitors
1998Decisions concerning the fate of a cell are intimately linked to the proliferative state of that cell. Proliferation of certain cell populations is required to maintain or repair tissues in an aging organism. However, this proliferation must be tightly regulated.
A, Carnero, G J, Hannon
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