The use of extrapolation based on modeling and simulation to support high‐dose regimens of ceftaroline fosamil in pediatric patients with complicated skin and soft‐tissue infections [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 A model‐informed drug development approach was used to select ceftaroline fosamil high‐dose regimens for pediatric patients with complicated skin and soft‐tissue infections caused by Staphylococcus aureus with a ceftaroline minimum inhibitory ...
Phylinda L.S. Chan +6 more
doaj +3 more sources
Systematic review of ceftaroline fosamil in the management of patients with methicillin-resistant Staphylococcus aureus pneumonia [PDF]
European Respiratory Review, 2023 Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for an array of problematic community- and healthcare-acquired infections, including pneumonia, and is frequently associated with severe disease and high mortality rates.
Antoní Torres +3 more
doaj +2 more sources
Pharmacokinetic and Pharmacodynamic Target Attainment in Adult and Pediatric Patients Following Administration of Ceftaroline Fosamil as a 5-Minute Infusion. [PDF]
Clin Pharmacol Drug Dev, 2021 Abstract The key pharmacokinetic/pharmacodynamic (PK/PD) efficacy index for β‐lactam antibiotics is the percentage of time that free drug concentrations exceed the minimum inhibitory concentration (MIC) of bacteria during each dosing interval (fT>MIC).
Riccobene TA +4 more
europepmc +2 more sources
Efficacy and Safety of Ceftaroline Fosamil in Hospitalized Patients with Community-Acquired Pneumonia in China: Subset Analysis of an International Phase 3 Randomized Controlled Trial [PDF]
Infection and Drug Resistance, 2022 Chao Zhuo,1 Yijiang Huang,2 Wenyuan Liu,3 Jin-Fu Xu,4 Wei Yun Zhu,5 Gregory G Stone,6 Jean Li Yan,7 Naglaa Mohamed8 1State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Diseases, Guangzhou Institute of ...
Zhuo C +7 more
doaj +2 more sources
Use of Ceftaroline Fosamil in Osteomyelitis: CAPTURE Study Experience [PDF]
BMC Infectious Diseases, 2019 Background Osteomyelitis is often challenging to treat. This analysis examined the clinical experience of patients with gram-positive osteomyelitis treated with ceftaroline fosamil in the phase 4 Clinical Assessment Program and Teflaro® Utilization ...
Leonard B. Johnson +2 more
doaj +2 more sources
Successful treatment of methicillin-resistant Staphylococcus aureus osteomyelitis and persistent bacteremia using adjunctive ceftaroline fosamil to vancomycin: A case report [PDF]
IDCasesBackground: Ceftaroline fosamil is a novel cephalosporin antibiotic effective against methicillin-resistant Staphylococcus aureus (MRSA). The FDA approved it in 2010 for the treatment of community-acquired pneumonia and acute bacterial skin and skin ...
Sufyan Mohammed Alomair +4 more
doaj +2 more sources
Journal of Global Antimicrobial Resistance, 2022 : Objectives: This exploratory pooled analysis assessed the efficacy and safety of ceftaroline fosamil and comparators across six phase III clinical trials in adults with community-acquired pneumonia (CAP) or complicated skin and soft-tissue infection ...
Matthew Dryden, Michal Kantecki
exaly +3 more sources
Baseline Characteristics and Outcomes Among Patients with Complicated Skin and Soft Tissue Infections Admitted to the Intensive Care Unit: Analysis of the Phase 3 COVERS Randomized Trial of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam [PDF]
Infectious Diseases and Therapy, 2020 Aim Exploratory analyses evaluated patient characteristics and outcomes among patients with complicated skin and soft tissue infection (cSSTI) in the phase 3 COVERS study who were admitted to an intensive care unit (ICU).
Miguel Sánchez-García +5 more
doaj +2 more sources
Efficacy and effectiveness of Ceftaroline Fosamil in patients with pneumonia: a systematic review and meta-analysis [PDF]
Respiratory Research, 2018 Background Pneumonia is a relevant clinical and public health issue worldwide frequently associated with infections caused by Multi-Drug Resistant (MDR) pathogens. Ceftaroline fosamil is a promising new antibiotics with broad-spectrum bacterial activity.
Giovanni Sotgiu +7 more
doaj +2 more sources
Real-World Use and Treatment Outcomes of Ceftaroline Fosamil in Patients with Complicated Skin and Soft Tissue Infection: A Multinational Retrospective Study [PDF]
Infection and Drug ResistanceTristan Ferry,1 Charalambos Gogos,2 Alex Soriano,3 Francesco Blasi,4,5 Wajeeha Ansari,6 Michal Kantecki,7 Bernd Schweikert,8 Gustavo Luna,9 Matteo Bassetti10 1Infectious Diseases Department, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France ...
Ferry T +8 more
doaj +2 more sources