Results 11 to 20 of about 1,567 (130)

Ceftaroline fosamil for the treatment of community-acquired bacterial pneumonia in the intensive care unit [PDF]

Therapeutics and Clinical Risk Management, 2015
Christy Maggiore,1 Jose A Vazquez,2 David J Guervil,3 Ananthakrishnan Ramani,4 Alena Jandourek,5 Phillip Cole,5 H David Friedland5 1Gulf Coast Medical Center, Panama City, FL, USA; 2Medical College of Georgia, Georgia Regents University, Augusta, GA ...
Maggiore C, Vazquez JA, Guervil DJ, Ramani A, Jandourek A, Cole P, Friedl, HD   +7 more
doaj   +3 more sources

Ceftaroline fosamil monotherapy for methicillin-resistant Staphylococcus aureus bacteremia: a comparative clinical outcomes study [PDF]

International Journal of Infectious Diseases, 2017
Objectives: Vancomycin is the treatment of choice for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, its use has been subject to scrutiny due to failure in severe infections. Ceftaroline fosamil (CPT-F) is approved for MRSA acute
Vanthida Huang, Samia Arshad, Marcus J Zervos   +2 more
exaly   +5 more sources

Plasma and parasternal subcutaneous tissue pharmacokinetics of ceftaroline fosamil in cardiac surgery with cardiopulmonary bypass [PDF]

Frontiers in Pharmacology
Surgical site infections remain significant complications after cardiac surgery and perioperative antibiotic exposure may be altered by cardiopulmonary bypass and patient characteristics.
Maximilian Edlinger-Stanger, Felix Bergmann, Walter Jaeger, Michaela Boehmdorfer, Markus Zeitlinger, Doris Hutschala-Kinstner   +5 more
doaj   +2 more sources

A Retrospective Analysis of Probability of Target Attainment in Community-Acquired Pneumonia: Ceftaroline Fosamil Versus Comparators [PDF]

Infectious Diseases and Therapy, 2019
Introduction This retrospective analysis compares the probability of target attainment (PTA) for ceftriaxone, levofloxacin and ceftaroline fosamil against Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae in a representative ...
Andrew Cristinacce, James G. Wright, Gregory G. Stone, Jennifer Hammond, Lynn McFadyen, Susan Raber   +5 more
doaj   +2 more sources

Ceftaroline Fosamil for the Empiric Treatment of Hospitalized Adults with cSSTI: An Economic Analysis from the Perspective of the Spanish National Health System [PDF]

ClinicoEconomics and Outcomes Research, 2022
Antoni Torres,1 Alex Soriano,2 Simone Rivolo,3 Edit Remak,4 Carmen Peral,5 Michal Kantecki,6 Wajeeha Ansari,7 Claudie Charbonneau,8 Jennifer Hammond,9 Santiago Grau,10 Mark Wilcox11 1Servei de Pneumologia Hospital Clinic, University of Barcelona, IDIPAPS,
Torres A, Soriano A, Rivolo S, Remak E, Peral C, Kantecki M, Ansari W, Charbonneau C, Hammond J, Grau S, Wilcox M   +10 more
doaj   +2 more sources

Ceftaroline Fosamil for the Treatment of Methicillin-Resistant Staphylococcus Aureus Bacteremia: A Real-World Comparative Clinical Outcomes Study [PDF]

Drugs - Real World Outcomes
Background and Objective Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia results in substantial morbidity and mortality. As current treatments often lead to unsatisfactory outcomes, evidence guiding alternative treatment options is needed ...
Jennifer Hammond, Michael Benigno, Nataly Bleibdrey, Wajeeha Ansari, Jennifer L. Nguyen   +4 more
doaj   +2 more sources

Spectrum and potency of ceftaroline against leading pathogens causing community-acquired respiratory tract and skin and soft tissue infections in Latin America, 2010 [PDF]

Brazilian Journal of Infectious Diseases, 2013
Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is a cephalosporin with in vitro bactericidal activity against Gram-positive organisms, including methicillinsusceptible and -resistant Staphylococcus aureus, β-haemolytic and ...
Robert K. Flamm, Helio S. Sader, Ronald N. Jones   +2 more
doaj   +5 more sources

Clinical Experience of Ceftaroline Fosamil in Gram-Positive Infective Endocarditis: A Multicenter Real-World Observational Study [PDF]

Antibiotics
Background/Objectives: Ceftaroline fosamil (CFT) is a fifth-generation cephalosporin approved in Spain for skin and soft tissue infections and community-acquired pneumonia. CFT may also be useful against endovascular infections.
Daniel Arnés-García, Jorge Calderón-Parra, Marina Calvo-Salvador, Carmen Herrero-Rodríguez, Svetlana Sadyrbaeva-Dolgova, Carmen Hidalgo-Tenorio   +5 more
doaj   +2 more sources

Ceftaroline fosamil – fifth-generation cephalosporin with anti-MRSA activity in the treatment of severe infections in pediatric practice [PDF]

Клиническая микробиология и антимикробная химиотерапия
Сeftaroline fosamil is a fifth-generation cephalosporin and a unique β-lactam and the only currently registered in the Russian Federation cephalosporin with activity against MRSA. Сeftaroline is approved for use in pediatric practice for the treatment of
Andreeva I.V., Stetsiouk O.U., Kozlov R.S.   +2 more
doaj   +3 more sources

In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication [PDF]

Viruses
The SARS-CoV-2 proteases Mpro and PLpro are critical targets for antiviral drug development for the treatment of COVID-19. The 1,2,4-thiadiazole functional group is an inhibitor of cysteine proteases, such as papain and cathepsins.
Cássia Delgado, Pablo Andrei Nogara, Milene Dias Miranda, Alice Santos Rosa, Vivian Neuza Santos Ferreira, Luisa Tozatto Batista, Thamara Kelcya Fonseca Oliveira, Folorunsho Bright Omage, Flávia Motta, Izabela Marques Bastos, Laura Orian, João Batista Teixeira Rocha   +11 more
doaj   +2 more sources