Results 1 to 10 of about 50,777 (219)

Prescribing patterns of celecoxib and prescribers′ perceptions among three general hospitals in Northern Malaysia

Archives of Pharmacy Practice, 2014
Objectives: This paper describes the clinical use of celecoxib in three major, government-subsidized hospitals across Northern Malaysia. Doctors′ perceptions of issues related to celecoxib and other nonsteroidal anti-inflammatory drugs (NSAIDs) were ...
Huan-Keat Chan, Ema Bakri, Sing-Yi Tan, Mohamed Azmi Hassali, Fahad Saleem, Tahir Mehmood Khan   +5 more
doaj   +1 more source

Computer-Aided Drug Repurposing: A Cyclooxygenase-2 Inhibitor Celecoxib as a Ligand for Estrogen Receptor Alpha

Indonesian Journal of Chemistry, 2015
A cyclooxygenase-2 (COX-2) inhibitor celecoxib has been previously reported to have cytotoxic activities towards gastric, prostate, ovarian, colon and breast cancer cell lines.
Enade Perdana Istyastono, Florentinus Dika Octa Riswanto, Sri Hartati Yuliani   +2 more
doaj   +1 more source

Safety of celecoxib versus traditional nonsteroidal anti-inflammatory drugs in older patients with arthritis

Journal of Pain Research, 2018
Sooyoung Shin1,2 1Department of Clinical Pharmacy, College of Pharmacy, Ajou University, Yeongtong-gu, Suwon, Republic of Korea; 2Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Yeongtong-gu, Suwon, Republic of Korea
Shin S
doaj  

Effects of Cetuximab Combined with Celecoxib on Apoptosis and KDR and AQP1 
Expression in Lung Cancer

Chinese Journal of Lung Cancer, 2013
Background and objective Neoadjuvant chemotherapy is a new development in the treatment of lung cancer. In recent years, cetuximab and celecoxib have been commonly used in this procedure.
Honggang XIA, Jianfei YE, Hongyu BAI, Changli WANG   +3 more
doaj   +1 more source

Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib

Journal of Lipid Research, 2013
The antitumorigenic mechanism of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib is still a matter of debate. Among different structurally related COX-2 inhibitors, only celecoxib was found to cause apoptosis and cell death of human lung ...
Robert Ramer, Udo Walther, Philipp Borchert, Stefan Laufer, Michael Linnebacher, Burkhard Hinz   +5 more
doaj   +1 more source

The cost-effectiveness of celecoxib versus non-steroidal anti-inflammatory drugs plus proton-pump inhibitors in the treatment of osteoarthritis in Saudi Arabia [PDF]

, 2015
Background: Cyclooxygenase (COX)-2 inhibitors including celecoxib are as effective as non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) in the treatment of osteoarthritis (OA) and have less gastrointestinal toxicity.
Ismail, Tarek A., Mould-Quevedo, Joaquin, Nasef, Sherif A., Shaaban, A. Aziz   +3 more
core   +1 more source

Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression.

PLoS ONE, 2019
The current study aimed to identify the radiosensitizing effect of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in combination with radiotherapy in non-small-cell lung cancer (NSCLC) cells. The combination of celecoxib potentiated radiation-
Pan Zhang, Dan He, Erqun Song, Mingdong Jiang, Yang Song   +4 more
doaj   +1 more source

Preparation and Characterization of Celecoxib Agglomerated Nanocrystals and Dry Powder Inhalation Formulations to Improve its Aerosolization Performance

Pharmaceutical Sciences, 2017
Background: Celecoxib is a non-steroidal anti-inflammatory drug used extensively in the treatment of pain, arthritis, and cancers. However, its administration is limited due to its several disadvantages including gastric irritation and hepatic first pass
Sepideh Mardani 1, Maryam Maghsoodi 2 * , Saeed Ghanbarzadeh 3,4, Ali Nokhodchi 5, Shadi Yaqoubi 6, Hamed Hamishehkar 7 *
doaj   +1 more source

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]

, 2018
During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey, Bon, Cox, Darwich, Dorey, Duwal, Ette, Fink, Jamei, Jamei, Jeunesse, Li, Li, Lin, Maaland, Margolskee, Margolskee, Martinez, Martinez, Martinez, Mochel, Mochel, Mochel, Mochel, Mochel, Mould, Ogungbenro, Pade, Pade, Paulson, Pelligand, Rey, Rostami-Hodjegan, Sheiner, Silber, Sjögren, Toutain, Tsamandouras, T’jollyn, Willmann, Zhuang   +40 more
core   +4 more sources

The dual role of CCND1 in heterotopic ossification: A Non-canonical Pathway for Celecoxib treatment

Heliyon
Objective: To explore the effective targets of Celecoxib in the treatment of heterotopic ossification using network pharmacology methods. Methods: Potential molecules related to heterotopic ossification were obtained by retrieving the GEO and CTD ...
Wei Liu, Junchao Huang, Jianhai Hu, Ziheng Bu, Zheng Zhou, Jianing Yu, Huajun Wang, Xinbo Wu, Peng Wu   +8 more
doaj   +1 more source