Results 1 to 10 of about 66,137 (309)

Celecoxib clinical profile [PDF]

Rheumatology, 2000
Celecoxib is the first COX-2-specific inhibitor approved for relief of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as for treatment of familial adenomatous polyposis. For both OA and RA, celecoxib has been shown to be significantly superior in efficacy to placebo and similar in efficacy to traditional non ...
Leslie Tive
openalex   +3 more sources

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling [PDF]

Scientific Reports, 2018
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen.
A Arfe, A Bauer, A Kardosh, A Salminen, AJ Shaywitz, B Fisslthaler, BR Gunter, C Liu, C Mo, C Patrono, CC Thornton, CH He, D Carling, DH Solomon, DM Thomson, EH Kobayashi, EL Fosbol, FY Li, H Mylroie, HP Lin, HT Cheng, I Tegeder, IE Schauer, J Lindhardsen, J Steffel, JA Mitchell, JM Cacicedo, JS Wang, K Iwasaki, K Zimmermann, LC Wu, ME Widlansky, MP Seldon, MP Soares, MT Nurmohamed, N Bhala, NJ Goodson, NM Davies, NM Davies, P Kale, PA Watson, R Chenevard, R Gozzelino, RS Bresalier, S Jacob, S Trelle, SE Nissen, SK Paulson, SK Paulson, SL Colombo, SS Hamdulay, SS Hamdulay, SW Ryter, TD Penning, TM MacDonald, VL King, WB White, X Liu, XM Liu, Y Hattori, ZQ Zou   +60 more
core   +6 more sources

Exacerbation of celecoxib-induced renal injury by concomitant administration of misoprostol in rats. [PDF]

PLoS ONE, 2014
Nonsteroidal anti-inflammatory drugs (NSAIDs) can produce adverse effects by inhibiting prostaglandin (PG) synthesis. A PGE1 analogue, misoprostol, is often utilized to alleviate NSAID-related gastrointestinal side effects. This study examined the effect
Dustin L Cooper, Derek E Murrell, Christopher M Conder, Victoria E Palau, Grace E Campbell, Shaun P Lynch, James W Denham, Angela V Hanley, Kenny W Bullins, Peter C Panus, Krishna Singh, Sam Harirforoosh   +11 more
doaj   +7 more sources

Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells [PDF]

International Journal of Nanomedicine, 2011
Tae-Ho Kim1*, Young-Il Jeong2*, Shu-Guang Jin2, Jian Pei2, Tae-Young Jung1, Kyung-Sub Moon1, In-Young Kim1, Sam-Suk Kang1, Shin Jung1,21Department of Neurosurgery, 2Brain Tumor Research Laboratory, Chonnam National University Research Institute of ...
Jung S., Kang SS, Kim IY, Jung TY, Pei J, Jin SG, Jeong YI, Kim TH   +7 more
doaj   +4 more sources

Celecoxib in breast cancer prevention and therapy. [PDF]

Cancer Management and Research, 2018
Breast cancer has a high incidence worldwide. The results of substantial studis reveal that inflammation plays an important role in the initiation, development, and aggressiveness of many malignancies. The use of celecoxib, a novel NSAID, is repetitively
Cao, Wei, Hao, Qiongyu, Li, Jieqing, Vadgama, Jaydutt V, Wu, Yong   +4 more
core   +2 more sources

Celecoxib for rheumatoid arthritis [PDF]

Cochrane Database of Systematic Reviews, 2002
Rheumatoid arthritis (RA) is a systemic auto-immune disorder, involving persistent joint inflammation. NSAIDs are used to control the symptoms of RA, but are associated with significant gastro-intestinal toxicity, including a risk of potentially life threatening gastroduodenal perforations, ulcers and bleeds.
Maria Judd, Peter Tugwell, Sarah Garner, Tanveer Towheed, Beverley Shea, Dogan Fidan, Ruth R Frankish, George A. Wells   +7 more
openaire   +5 more sources

Celecoxib concentration predicts decrease in prostaglandin E₂ concentrations in nipple aspirate fluid from high risk women [PDF]

BMC Cancer, 2008
Background Epidemiologic studies suggest that long term low dose celecoxib use significantly lowers breast cancer risk. We previously demonstrated that 400 mg celecoxib taken twice daily for 2 weeks lowered circulating plasma and breast nipple aspirate ...
Flynn John T, Ruhlen Rachel L, Hewett John E, Qin Wenyi, Sauter Edward R, Rottinghaus George, Chen Yin-Chieh   +6 more
doaj   +4 more sources

Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2 [PDF]

Journal of Experimental & Clinical Cancer Research, 2008
Background The goal of this study was to determine the effects of a selective Cyclooxygenase (COX)-2 inhibitor on the inhibition of tumor growth and pulmonary metastasis in a Lewis Lung Carcinoma (LLC) animal model. Methods For immunoblot analysis of COX-
Han Jae, Oh Young, Park Won, Pyo Hongryull   +3 more
doaj   +5 more sources

Cytokinesis-block micronucleus assay of celecoxib and celecoxib derivatives

Toxicology Reports, 2020
Celecoxib is used widely for the acute treatment of pain and for pain relief in various diseases. Furthermore, it shows potential in chemoprevention, although chronic treatment with celecoxib could lead to adverse effects like cardiovascular events.
Hauke Reimann, Quoc Anh Ngo, Helga Stopper, Henning Hintzsche   +3 more
doaj   +4 more sources

Celecoxib and rofecoxib have different effects on small intestinal ischemia/reperfusion injury in rats [PDF]

Frontiers in Pharmacology
IntroductionIntestinal ischemia/reperfusion (I/R) injury is associated with high mortality and there is an unmet need for novel therapies. The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a ...
Szilvia B. László, Barbara Hutka, Barbara Hutka, András S. Tóth, András S. Tóth, Tamás Hegyes, Zsuzsanna O. Demeter, Zsuzsanna O. Demeter, Arezoo Haghighi, Arezoo Haghighi, Gerda Wachtl, Gerda Wachtl, Ágnes Kelemen, Anna Jakab, Klára Gyires, Klára Gyires, Zoltán S. Zádori, Zoltán S. Zádori   +17 more
doaj   +2 more sources