Results 11 to 20 of about 50,777 (219)

Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2 [PDF]

Journal of Experimental & Clinical Cancer Research, 2008
Background The goal of this study was to determine the effects of a selective Cyclooxygenase (COX)-2 inhibitor on the inhibition of tumor growth and pulmonary metastasis in a Lewis Lung Carcinoma (LLC) animal model. Methods For immunoblot analysis of COX-
Han Jae, Oh Young, Park Won, Pyo Hongryull   +3 more
doaj   +3 more sources

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G₁ cell cycle arrest and autophagy [PDF]

Molecular Cancer, 2009
Background Selective cyclooxygenase (COX)-2 inhibitors elicit anti-proliferative responses in various tumours, however the underlying anti-tumour mechanisms are unclear.
Gao Qiuhan, Yong Sook, Zhu Congju, Kang Khong, Wong Meng   +4 more
doaj   +3 more sources

Whole-gene CRISPR/cas9 library screen revealed targeting STAT6 increased the sensitivity of liver cancer to celecoxib via inhibiting arachidonic acid shunting [PDF]

Cell Communication and Signaling
Celecoxib, a selective COX-2 inhibitor, has demonstrated anti-liver cancer effects in various preclinical models and clinical traits. However, prolonged use of celecoxib can lead to drug resistance, necessitating higher doses to maintain efficacy, which ...
Chujiao Hu, Zhirui Zeng, Xin Bao, Dahuan Li, Huading Tai, Haohao Zeng, Cheng Luo, Lei Tang, Tengxiang Chen, Shi Zuo   +9 more
doaj   +2 more sources

Celecoxib

Drugs, 2012
Hoofnagle JH.
exaly   +3 more sources

Effect of Cyclooxygenase-2 Inhibitors in Double J Stent Removal under Local Anesthesia

The Annals of African Surgery, 2021
Introduction: Celecoxib is a selective cyclooxygenase-2(COX-2) inhibitor that can reduce the inflammatory process during double J (DJ) stent removal procedure.
Rulianov Rulianov, Jumadi Santoso, Aryo Teguh Abriansyah, Safendra Siregar   +3 more
doaj   +1 more source

Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib

Pharmaceutics, 2020
Although celecoxib is quite effective in the management of inflammation-related diseases, especially arthritis, its use is limited by concerns including low bioavailability (BA), non-linear pharmacokinetic (PK) profile, and peak concentration-related ...
Yonghyun Lee, Jungyun Kim, Wooseong Kim, In-Soo Yoon, Yunjin Jung   +4 more
doaj   +1 more source

Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
New thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC50 = 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib (IC50 =
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Mohamed G. Bekhit, Saad R. El-Zemity, Rasha A. Nassra, Aly A. Hazzaa   +5 more
doaj   +1 more source

CELECOXIB

The Professional Medical Journal, 2018
Objective: To observe the absolute, relative weight of kidney and body weightof albino rats on celecoxib induced kidney with protection by lycopene. Study Design:Experimental study. Place and Duration of study: This study was conducted in BMSI (Anatomydepartment), JPMC, Karachi, from 4th May 2015 to 3rd June 2015.
Sadia Sundus, Nazia Qamar, Raheela Adil, Muhammad Faisal Fahim   +3 more
  +6 more sources

Inhibition mechanism of the intracellular transporter Ca2+-pump from sarco-endoplasmic reticulum by the antitumor agent dimethyl-celecoxib. [PDF]

PLoS ONE, 2014
Dimethyl-celecoxib is a celecoxib analog that lacks the capacity as cyclo-oxygenase-2 inhibitor and therefore the life-threatening effects but retains the antineoplastic properties. The action mechanism at the molecular level is unclear.
Ramón Coca, Fernando Soler, Ernesto Cortés-Castell, Vicente Gil-Guillén, Francisco Fernández-Belda   +4 more
doaj   +1 more source

Screening for autophagy/hypoxia/ferroptosis/pyroptosis-related genes of tendon injury and repair in a rat model after celecoxib and lactoferrin treatment

Journal of Orthopaedic Surgery and Research, 2023
Background Tendon injuries are among the most common musculoskeletal disorders. Celecoxib possesses an effective anti-inflammatory activity in the tendon injury treatment. Lactoferrin has a great potential for the tendon regeneration.
Yaonan Zhang, Lei Shi, Fei Wang, Lin Wang, Nan Min, Liangyuan Wen, Qingyun Xue   +6 more
doaj   +1 more source