Results 21 to 30 of about 66,137 (309)
Pharmaceutics, 2020 Although celecoxib is quite effective in the management of inflammation-related diseases, especially arthritis, its use is limited by concerns including low bioavailability (BA), non-linear pharmacokinetic (PK) profile, and peak concentration-related ...
Yonghyun Lee +4 more
doaj +1 more source
Current Oncology, 2022 The purpose of this meta-analysis was to evaluate the efficacy and safety of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in addition to standard anticancer therapy. Randomized controlled trials (RCTs) that evaluated the efficacy and safety
Shi-Yu Ye +10 more
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2023 Background Tendon injuries are among the most common musculoskeletal disorders. Celecoxib possesses an effective anti-inflammatory activity in the tendon injury treatment. Lactoferrin has a great potential for the tendon regeneration.
Yaonan Zhang +6 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 New thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC50 = 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib (IC50 =
Mostafa M. M. El-Miligy +5 more
doaj +1 more source
Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells. [PDF]
PLoS ONE, 2013 Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, can elicit anti-tumor effects in various malignancies. Here, we sought to clarify the role of autophagy in celecoxib-induced cytotoxicity in human urothelial carcinoma (UC) cells.
Kuo-How Huang +12 more
doaj +1 more source
Frontiers in Immunology, 2022 ObjectiveTo investigate the efficacy and safety of clinical, magnetic resonance imaging (MRI) changes in active ankylosing spondylitis (AS) patients with etanercept and celecoxib alone/combined treatment.MethodsA randomized controlled trial was conducted
Liudan Tu +16 more
doaj +1 more source
Explainable Artificial Intelligence for Pharmacovigilance: What Features Are Important When Predicting Adverse Outcomes? [PDF]
, 2021 Explainable Artificial Intelligence (XAI) has been identified as a viable method for determining the importance of features when making predictions using Machine Learning (ML) models. In this study, we created models that take an individual's health information (e.g.
arxiv +1 more source
Celecoxib for rheumatoid arthritis [PDF]
Cochrane Database of Systematic Reviews, 2016 Rheumatoid arthritis is a systemic auto-immune disorder that causes widespread and persistent inflammation of the synovial lining of joints and tendon sheaths. Presently, there is no cure for rheumatoid arthritis and treatment focuses on managing symptoms such as pain, stiffness and mobility, with the aim of achieving stable remission and improving ...
Mahir Fidahic +3 more
openaire +3 more sources
Journal of the American Medical Association (JAMA), 2000 CONTEXT Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1.
F. Silverstein +15 more
semanticscholar +1 more source
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
New England Journal of Medicine, 2000 BACKGROUND Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2 ...
G. Steinbach +23 more
semanticscholar +1 more source