Results 151 to 160 of about 1,318,238 (218)

Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma. [PDF]

EMBO Mol Med
Richardson SA, Safrastyan A, Karimpour M, Gulati G, Harker PJB, Redfern A, Pearce SP, Makeev VJ, Brennan B, Lee ATJ, Clipson A, Hill SM, Dive C, Rothwell DG, McCabe MG, Mouliere F.   +15 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Application of a modified MSRE-qPCR method for detecting circulating cell-free DNA methylation in cervical cancer. [PDF]

Front Oncol
Liu Y, He T, Chen S, Wang S, Luo Z, Liu H, Liu Q, Luo D.   +7 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Non-disruptive in vitro monitoring of cellular states with cell-free DNA methylation. [PDF]

Genome Biol
Hess A, Kovacsovics A, Bachinger F, Vallier L, Kretzmer H, Meissner A.   +5 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Advances in donor-derived cell-free DNA monitoring for solid organ transplantation. [PDF]

Front Immunol
Sairafi D, Foord E, Pettersson L, Uhlin M.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Cancer of unknown primary genomic profiling from cell-free DNA provides insights into CUP biology and vulnerabilities. [PDF]

Front Med (Lausanne)
Roncarati R, Fontana B, Pace I, Durante G, Conci N, Soru A, Gallerani G, Riefolo M, Salamon I, Laprovitera N, Broseghini E, Naddeo M, Espis A, Sales G, Diciotti S, D'Errico A, Rihawi K, Ardizzoni A, Ferracin M.   +18 more
europepmc   +1 more source