Results 261 to 270 of about 4,735,099 (379)

Chemical and Biological Characterization of Metabolites from Silene viridiflora Using Mass Spectrometric and Cell-Based Assays. [PDF]

Biomolecules
Mamadalieva NZ, Koval A, Dusmuratov MM, Hussain H, Katanaev VL.   +4 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Cell-based assays and comparative genomics revealed the conserved and hidden effects of Wolbachia on insect sex determination. [PDF]

PNAS Nexus
Arai H, Herran B, Sugimoto TN, Miyata M, Sasaki T, Kageyama D.   +5 more
europepmc   +1 more source

High-throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays. [PDF]

Biophys J, 2021
Dos Santos Á, Fili N, Pearson DS, Hari-Gupta Y, Toseland CP.   +4 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Induced pluripotent stem cell-based assays recapture multiple properties of human astrocytes. [PDF]

J Cell Mol Med
Nonaka H, Kondo T, Suga M, Yamanaka R, Sagara Y, Tsukita K, Mitsutomi N, Homma K, Saito R, Miyoshi F, Ohzeki H, Okuyama M, Inoue H.   +12 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Exploiting Cell-Based Assays to Accelerate Drug Development for G Protein-Coupled Receptors. [PDF]

Int J Mol Sci
Wu Y, Jensen N, Rossner MJ, Wehr MC.
europepmc   +1 more source

High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes. [PDF]

SLAS Discov, 2022
Kassner M, Eaton JB, Tang N, Petit JL, Meurice N, Yin HH, Whiteaker P.   +6 more
europepmc   +1 more source

The regulation of circulating ghrelin - with recent updates from cell-based assays.

Endocrine journal, 2015
H. Iwakura, K. Kangawa, K. Nakao
semanticscholar   +1 more source