Results 91 to 100 of about 10,355,590 (280)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Cell-Free DNA in Ischemic Stroke [PDF]

Stroke, 2022
Sarina R. Falcione, Glen C. Jickling
openaire   +2 more sources

Implementing prenatal diagnosis based on cell-free fetal DNA: accurate identification of factors affecting fetal DNA yield.

PLoS ONE, 2011
ObjectiveCell-free fetal DNA is a source of fetal genetic material that can be used for non-invasive prenatal diagnosis. Usually constituting less than 10% of the total cell free DNA in maternal plasma, the majority is maternal in origin.
Angela N Barrett, Bernhard G Zimmermann, Darrell Wang, Andrew Holloway, Lyn S Chitty   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Cell-free DNA promotes malignant transformation in non-tumor cells

Scientific Reports, 2020
Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of cells adjacent to the tumor and metastasis. Thus, this study analyzed the effect of tumor cell-
Aline Gomes de Souza, Victor Alexandre F. Bastos, Patricia Tieme Fujimura, Izabella Cristina C. Ferreira, Letícia Ferro Leal, Luciane Sussuchi da Silva, Ana Carolina Laus, Rui Manuel Reis, Mario Machado Martins, Paula Souza Santos, Natássia C. Resende Corrêa, Karina Marangoni, Carolina Hassibe Thomé, Leandro Machado Colli, Luiz Ricardo Goulart, Vivian Alonso Goulart   +15 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Molecular features unique to circulating tumor DNA enable the tumor-naïve liquid biopsy of glioblastoma

npj Precision Oncology
Glioblastoma is the most common and deadly brain cancer in adults. Although the disease disrupts the blood-brain barrier and exposes the tumor to the systemic circulation, using circulating cell-free DNA as a non-invasive biomarker for diagnosing ...
Hunter R. Underhill, Drew L. Sellers, Sabine Hellwig, Hediyeh Baradaran, Mary P. Bronner, Alun Thomas, Sarah Menacho, Christian J. Davidson, Rachna Malani, Andrew Farrell, Michael Karsy, David A. Nix, Yingqi Zhang, Laura A. Boatz, Joe Mendez, Lindsay Burt, Donald Cannon, Charlie S. Dean, Brion E. Harrison, Samuel Stevenson, Kinga Aitken, Stefan M. Pulst, Howard Colman, Randy L. Jensen   +23 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Cell-free DNA fragmentomics in cancer

Cancer Cell
The analysis of cell-free DNA (cfDNA) fragmentation patterns, known as "fragmentomics," has opened new opportunities in noninvasive cancer diagnostics. Due to its close relationships with genomic organization and cell death, cfDNA fragmentomics lies at the intersection of many aspects of cancer biology, including epigenetic dysregulation ...
W H Adrian, Tsui, Peiyong, Jiang, Y M Dennis, Lo   +2 more
openaire   +2 more sources