Results 71 to 80 of about 3,251,205 (352)

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei [PDF]

, 1992
Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved by postreplicative methylation of newly synthesized DNA. DNA methyltransferase (MTase) is here shown to associate with replication foci during S phase but
Heinz-Ulrich Weier, Page, A.W., Weier, H.U., Andrea W. Page, Bestor, Timothy H., Bestor, T. H., Heinrich Leonhardt, Page, A. W., Page, Andrea W., Leonhardt, Heinrich, Weier, H. U., Weier, Heinz-Ulrich, Bestor, T.H., Timothy H. Bestor, Leonhardt, H.   +14 more
core   +1 more source

Cancer Detection from Plasma Cell-Free DNA [PDF]

E3S Web of Conferences, 2020
Liquid biopsy of cell-free DNA (cfDNA) has attracted much attention for its promise to realize pan-cancer detection in a non-invasive way. The whole-genome bisulfite sequencing (WGBS) is widely used in cfDNA sequencing analysis and lays the foundation ...
Chen Li
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma.

Journal of Clinical Oncology, 2019
PURPOSE Novel sensitive methods for early detection of relapse and for monitoring therapeutic efficacy may have a huge impact on risk stratification, treatment, and ultimately outcome for patients with bladder cancer.
E. Christensen, K. Birkenkamp-Demtröder, H. Sethi, S. Shchegrova, R. Salari, I. Nordentoft, Hsin-Ta Wu, M. Knudsen, P. Lamy, S. Lindskrog, A. Taber, M. Balcioğlu, Søren Vang, Z. Assaf, Shruti Sharma, Antony S. Tin, R. Srinivasan, D. Hafez, T. Reinert, S. Navarro, A. Olson, Rosalyn Ram, S. Dashner, M. Rabinowitz, P. Billings, S. Sigurjonsson, C. Andersen, R. Swenerton, A. Aleshin, B. Zimmermann, M. Agerbæk, C. J. Lin, J. B. Jensen, L. Dyrskjøt   +33 more
semanticscholar   +1 more source

Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Cell-free DNA (cfDNA) fragmentation patterns carry a wealth of information related to DNA nuclease activities and tissues of origin. However, there is a lack of tools for obtaining a bird’s eye view of the involvement of nucleases and other ...
Ze Zhou, Mary-Jane L. Ma, R. Chan, W. Lam, Wenlei Peng, W. Gai, Xi Hu, Spencer C. Ding, Lu Ji, Qing Zhou, P. Cheung, Stephanie C. Y. Yu, Jeremy Y. C. Teoh, C. Szeto, J. Wong, V. W. Wong, G. Wong, S. Chan, E. Hui, B. Ma, A. Chan, R. Chiu, K. C. Chan, Y. Lo, P. Jiang, WT Dnase1   +25 more
semanticscholar   +1 more source

Changes in the nuclear distribution of DNA polymerase alpha and PCNA/cyclin during the progress of the cell cycle, in a cell-free extract of Xenopus eggs [PDF]

, 1989
The nuclear distribution of DNA polymerase alpha and PCNA/cyclin in embryonic nuclei has been investigated, in a cell-free extract of Xenopus eggs that recapitulates a basic cell-cycle in vitro, by indirect immunofluorescence microscopy.
Kill, IR, Hutchison, C
core  

Specific antigen of tumor cell transformed by DNA extracted from SV-40 virus [PDF]

, 1967
In the immunofluorescent study it has been revealed that rabbit sera immunized with transformed cells induced by SV-40 DNA, produce circulating antibody capable of re:lcting with intranuclear antigens synthesized by SV-40 complyte virus transforming ...
Okada, Shigeru, Grace, James T., Hayashi, Kenj, Kimoto, Tetsuo, Sogabe, Koichi, Shigehisa, Morio   +5 more
core   +1 more source

A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

Nature Communications, 2022
Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome protection and accessibility from cfDNA to study the phenotype of ...
Anna-Lisa Doebley, Minjeong Ko, Hanna Liao, A. Cruikshank, Katheryn Santos, C. Kikawa, Joseph B Hiatt, R. Patton, N. De Sarkar, K. Collier, A. Hoge, Katharine Chen, A. Zimmer, Z. Weber, M. Adil, J. Reichel, P. Polak, V. Adalsteinsson, P. Nelson, D. MacPherson, H. Parsons, D. Stover, G. Ha   +22 more
semanticscholar   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source