Results 61 to 70 of about 3,251,205 (352)
Cell-free DNA approaches for cancer early detection and interception
Journal for ImmunoTherapy of Cancer, 2023 Rapid advancements in the area of early cancer detection have brought us closer to achieving the goals of finding cancer early enough to treat or cure it, while avoiding harms of overdiagnosis.
J. Medina +7 more
semanticscholar +1 more source
University of Western Ontario Medical Journal, 2020 Chromosomal disorders arise from errors in cell division and many are detected during prenatal development. Prenatal genomic screening techniques involve invasive methods such as chorionic villus sampling and amniocentesis. In this feature, current invasive techniques for genetic screening will be examined in relation to the development of non-invasive
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Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]
, 2014 Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Jaiswal, H. +9 more
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Comparison of methods for the quantification of cell-free DNA isolated from cell culture supernatant
Tumor Biology, 2019 Gaining a better understanding of the biological properties of cell-free DNA constitutes an important step in the development of clinically meaningful cell-free DNA–based tests.
Abel Jacobus Bronkhorst +2 more
doaj +1 more source
Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis
Nature Communications, 2022 Periodontitis is a common type of inflammatory bone loss and a risk factor for systemic diseases. The pathogenesis of periodontitis involves inflammatory dysregulation, which represents a target for new therapeutic strategies to treat periodontitis ...
Hanyao Huang +14 more
semanticscholar +1 more source
DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]
, 2002 Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D. +11 more
core +1 more source
Cell-Free DNA Fragmentomics: The Novel Promising Biomarker
International Journal of Molecular Sciences, 2023 Cell-free DNA molecules are released into the plasma via apoptotic or necrotic events and active release mechanisms, which carry the genetic and epigenetic information of its origin tissues.
Ting Qi +5 more
semanticscholar +1 more source
Clinical Cancer Research, 2019 Purpose: Complete and timely tissue genotyping is challenging, leading to significant numbers of patients with newly diagnosed metastatic non–small cell lung cancer (mNSCLC) being undergenotyped for all eight genomic biomarkers recommended by ...
N. Leighl +10 more
semanticscholar +1 more source
Cell-free DNA analysis in current cancer clinical trials: a review
British Journal of Cancer, 2022 Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment selection and clinical follow-up of cancer patients. Although its general methodological feasibility and usefulness has been demonstrated, several issues related to
M. Cisneros-Villanueva +13 more
semanticscholar +1 more source
Clinical Chemistry, 2012 In 1947, Mandel and Metais discovered the unusual phenomenon of circulating cell-free DNA (1). Although one might naively think that DNA is found only in the nuclei of cells, it turns out that a substantial amount of small DNA fragments circulates within the blood.
openaire +2 more sources