Results 61 to 70 of about 10,355,590 (280)
Indian Journal of TransplantationDonor-derived cell-free deoxyribonucleic acid (dd-cfDNA) is a promising noninvasive biomarker for monitoring organ transplant rejection and graft status as it is released into the recipient’s bloodstream due to graft injury, ischemia, or immune response.
Vikash Chandra Mishra +2 more
doaj +1 more source
Cell-free DNA in non-small cell lung cancer
Acta Medica Lituanica, 2017 Lung cancer is the leading cause of cancer-associated deaths worldwide. Surgery is the standard treatment for early-stage non-small cell lung cancer (NSCLC).
Vaida Gedvilaitė +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cell‐free DNA results lead to unexpected diagnosis
Clinical Case Reports, 2017 Key Clinical Message Maternal cell‐free DNA (cfDNA) results that are discordant with the diagnostic fetal karyotype should prompt further investigation.
Jessica Smith +6 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The timing of the formation and usage of replicase clusters in S-phase nuclei of human diploid fibroblasts [PDF]
, 1991 The sites of nascent DNA synthesis were compared with the distribution of the proliferating cell nuclear antigen (PCNA) in S-phase nuclei of human diploid fibroblasts (HDF) by two in vitro techniques.
Kill, IR +4 more
core +4 more sources
Tumor Biology, 2018 In late-stage metastatic colorectal cancer, difficult treatment decisions should incorporate a thorough evaluation of the patient’s general condition and subject for shared decision making.
Karen-Lise Garm Spindler +8 more
doaj +1 more source
Cell free DNA as a marker of training status in weightlifters
Biology of Sport, 2017 The purpose of this investigation was to elucidate the changes in cf-DNA as it relates to fluctuations in resistance training workloads and intensities.
Jeremy A. Gentles +6 more
doaj +1 more source
Cell-Free DNA in Emergency Medical Care
Неотложная медицинская помощь, 2020 . Defining molecules with high prognostic value for predicting the course and outcomes of life-threatening sepsis, severe injuries, vascular accidents remains an urgent problem in emergency medicine. One of the promising candidate biomarkers of emergency
A. D. Filev, V. M. Pisarev
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source