Results 51 to 60 of about 3,251,205 (352)
Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]
, 2015 Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K. +27 more
core +1 more source
Detecting Liver Cancer Using Cell-Free DNA Fragmentomes
Cancer Discovery, 2022 A machine learning model using multifeature fragmentome data from genome-wide cell-free DNA analyses detected hepatocellular carcinoma with high sensitivity and specificity in average and high-risk populations, including in early-stage disease.
Zachariah H. Foda +20 more
semanticscholar +1 more source
Circulating Cell-Free DNA in Cancer
, 2014 This papers deals with the preanalytical and analytical phase of cell-free DNA analysis, highlighting some criticism on sample collection and extraction. We describe a method to accurately quantify total cfDNA in plasma and our particular approach to the measurement of tumor deriving cfDNA.
PINZANI, PAMELA +3 more
openaire +3 more sources
Tumor Biology, 2017 Head and neck squamous cell carcinoma is the most commonly diagnosed cancer worldwide. The lifestyle, food habits, and customary practices manifest the Northeast Indian population toward higher susceptibility to develop head and neck squamous cell ...
Manish Kumar +7 more
doaj +1 more source
Cell-free DNA as a biomarker in cancer
Extracellular Vesicles and Circulating Nucleic Acids, 2022 Translational research of liquid biopsy is just at the edge of routine clinical application: an emerging validity of circulating tumor DNA (ctDNA) tests suggests its use for earlier cancer detection and better monitoring of minimal residual disease (MRD) and resistance development, thus offering earlier guidance for therapy choices with the intent to ...
Robert H. Eibl, Markus Schneemann
openaire +2 more sources
Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells [PDF]
, 2009 © 2009 by The American Society for Cell Biology.The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a component
Modino, S +17 more
core +1 more source
Nature Communications, 2022 Recent advances in biointerfaces have led to the development of wearable devices that can provide insights into personal health. As wearable modules, microneedles can extract analytes of interest from interstitial fluid in a minimally invasive fashion ...
Bin Yang, J. Kong, Xueen Fang
semanticscholar +1 more source
Cell-Free DNA as an Obesity Biomarker
Physiological Research, 2020 Obesity is a disease that affects about 13 % of the world population (2016) (Who 2018). This condition generates a process of systemic inflammation that may contribute to the release of cell-free DNA (cfDNA) into the bloodstream. cfDNA has been considered a potential biomarker to monitor several physiological and pathological conditions, such as tumors,
P V, Camuzi Zovico +6 more
openaire +2 more sources
Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Soh, Young-Min +69 more
core +1 more source
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring
Nature Medicine, 2020 In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments ...
Asaf Zviran +41 more
semanticscholar +1 more source