Results 141 to 150 of about 3,251,205 (352)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

DNA demethylation triggers cell free DNA release in colorectal cancer cells

Genome Medicine
Background Liquid biopsy based on cell-free DNA (cfDNA) analysis holds significant promise as a minimally invasive approach for the diagnosis, genotyping, and monitoring of solid malignancies.
Valeria Pessei, Marco Macagno, Elisa Mariella, Noemi Congiusta, Vittorio Battaglieri, Paolo Battuello, Marco Viviani, Giulia Gionfriddo, Simona Lamba, Annalisa Lorenzato, Daniele Oddo, Fariha Idrees, Alessandro Cavaliere, Alice Bartolini, Simonetta Guarrera, Michael Linnebacher, Laura Monteonofrio, Luca Cardone, Michele Milella, Andrea Bertotti, Silvia Soddu, Elena Grassi, Giovanni Crisafulli, Alberto Bardelli, Ludovic Barault, Federica Di Nicolantonio   +25 more
doaj   +1 more source

Circulating cell-free DNA biomarkers

APIK Journal of Internal Medicine, 2021
Jose Rafael Villarreal Escorcia
doaj   +1 more source

Circulating Cell Free DNA and DNA Double-Strand Breakage in Alzheimer’s Disease

Journal of Alzheimer's Disease Reports
Alzheimer’s disease (AD) is an age-related neurodegenerative disease that is characterized by memory loss and multiple cognitive impairments. AD is pathologically characterized by age-dependent accumulation of amyloid-β protein and the phosphorylation of
Michelle Nguyen, Colby Wood, Andres Rios, Zach Salter, P. Hemachandra Reddy   +4 more
doaj   +1 more source

Implementing prenatal diagnosis based on cell-free fetal DNA: accurate identification of factors affecting fetal DNA yield.

PLoS ONE, 2011
ObjectiveCell-free fetal DNA is a source of fetal genetic material that can be used for non-invasive prenatal diagnosis. Usually constituting less than 10% of the total cell free DNA in maternal plasma, the majority is maternal in origin.
Angela N Barrett, Bernhard G Zimmermann, Darrell Wang, Andrew Holloway, Lyn S Chitty   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The role of protein kinases in DNA replication in Saccharomyces cerevisiae [PDF]

, 2010
The initiation of DNA replication at the onset of S phase in eukaryotic cells is a critically important and tightly regulated process. Multiple origins of replication in the genome must be co-ordinately regulated such that duplication of the chromosomes ...
Sweet, S.
core  

ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair [PDF]

, 2008
Background: The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the resistant cell lines have a cell
Davey, Ross, Stordal, Britta
core   +1 more source

Cell-free DNA promotes malignant transformation in non-tumor cells

Scientific Reports, 2020
Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of cells adjacent to the tumor and metastasis. Thus, this study analyzed the effect of tumor cell-
Aline Gomes de Souza, Victor Alexandre F. Bastos, Patricia Tieme Fujimura, Izabella Cristina C. Ferreira, Letícia Ferro Leal, Luciane Sussuchi da Silva, Ana Carolina Laus, Rui Manuel Reis, Mario Machado Martins, Paula Souza Santos, Natássia C. Resende Corrêa, Karina Marangoni, Carolina Hassibe Thomé, Leandro Machado Colli, Luiz Ricardo Goulart, Vivian Alonso Goulart   +15 more
doaj   +1 more source

Cell‐free fetal DNA in celomic fluid

Ultrasound in Obstetrics & Gynecology, 2008
Ultrasound Obstet ...
Makrydimas, G., Gerovassili, A., Sotiriadis, A., Kavvadias, A., Nicolaides, K. H.   +4 more
openaire   +4 more sources